WNK4
WNK4 is the kidney-centric WNK kinase, expressed along the distal nephron where it fine-tunes electrolyte transport and blood pressure. It inhibits the thiazide-sensitive NCC and the Na-K-2Cl cotransporter NKCC2, the potassium channel ROMK, and the calcium channel TRPV5, with its effects depending on phosphorylation state and interaction with SPAK/OSR1. WNK4 was the first WNK linked to human disease: missense mutations in its acidic domain cause pseudohypoaldosteronism type II (Gordon syndrome), characterized by hypertension, hyperkalemia and metabolic acidosis that respond to thiazide diuretics. Recombinant WNK4 is widely used to dissect chloride sensing and distal-tubule transport regulation.
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WNK4 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
