2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Amosulalol

Amosulalol  (Synonyms: YM 09538)

Cat. No.: HY-106720 Purity: 98.69%
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Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR).

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Amosulalol Chemical Structure

Amosulalol Chemical Structure

CAS No. : 85320-68-9

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Based on 1 publication(s) in Google Scholar

Amosulalol Related Antibodies

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Description

Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR)[1].

IC50 & Target[1]

α1-adrenergic receptor

 

Beta-1 adrenergic receptor

 

In Vivo

Amosulalol (3-30 mg/kg; p.o.; single dose) reduces acute systolic blood pressure in hypertensive rats[1].
Amosulalol (50 mg/kg; p.o.; twice daily for 12 weeks) produces an intolerant antihypertensive effect and also reduces central rate and increases PRA in hypertensive rat models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

380.46

Formula

C18H24N2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NS(=O)(C1=CC(C(O)CNCCOC2=C(C=CC=C2)OC)=CC=C1C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
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References
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Amosulalol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amosulalol85320-68-9YM 09538YM09538YM-09538Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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