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Cat. No.: HY-W707863

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Lercanidipine-d₃

Lercanidipine-d₃ is the deuterium labeled Lercanidipine (HY-B0612). Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective and orally active dihydropyridine-calcium channel blocker with a pIC₅₀ of 7.74 (converts from μM). Lercanidipine has long lasting antihypertensive action as well as reno- and neuro-protective effect. Lercanidipine also shows anti-oxidant, anti-inflammatory and anti-apoptotic properties. Lercanidipine can be used in cardiovascular and neurological research.

For research use only. We do not sell to patients.

CAS No.: 1190043-34-5
Formula: C₃₆H₃₈D₃N₃O₆
Molecular Weight:614.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (246 KB)

Lercanidipine-d₃ Chemical Structure

CAS No.: 1190043-34-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Application
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Biological Activity

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1190043-34-5
Unlabeled Cas 100427-26-7
Molecular Weight 614.75
Formula C₃₆H₃₈D₃N₃O₆
SMILES

O=C(C1=C(NC(C)=C(C1C2=CC=CC([N+]([O-])=O)=C2)C(OC)=O)C)OC(C)(CN(CCC(C3=CC=CC=C3)C4=CC=CC=C4)C([2H])([2H])[2H])C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.