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Cat. No.: HY-119379

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Fonsartan free acid

(Synonyms: HOE-720 free acid)

Fonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC₅₀ value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID₅₀ = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases.

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CAS No.: 144628-52-4
Formule: C₂₆H₃₂N₄O₅S₂
Masse moléculaire:544.69

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Fonsartan free acid Chemical Structure

CAS No.: 144628-52-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

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Chemical Information

CAS No. 144628-52-4
Masse moléculaire 544.69
Formule C₂₆H₃₂N₄O₅S₂
SMILES

O=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(NC(NCCC)=O)=O)C=CC=C3)C=C2)O
Synonyms

HOE-720 free acid
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Deprez P, et al. Sulfonylureas and sulfonylcarbamates as new non-tetrazole angiotensin II receptor antagonists. Discovery of a highly potent orally active (imidazolylbiphenylyl)sulfonylurea (HR 720). J Med Chem. 1995 Jun 23;38(13):2357-77. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Fonsartan free acid

Voir tous les produits spécifiques à Isoform Angiotensin Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Fonsartan free acid Related Classifications

HY-119379 Related Classifications