144628-52-4
Chemical Structure
Fonsartan free acid
Synonym(s): HOE-720 free acid
- CAS No.: 144628-52-4
- Formula:C26H32N4O5S2
- Molecular Weight:544.69
IUPAC Name: 2-butyl-4-(methylthio)-1-((2'-(N-(propylcarbamoyl)sulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid
InChIKey: DKCCTYVLJMSFOG-UHFFFAOYSA-N
SMILES: O=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(NC(NCCC)=O)=O)C=CC=C3)C=C2)O
Biological Activity: Fonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases[1].
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Fonsartan free acid | Fonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases. | |||||||||||||||||||||
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Keywords
