1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
    AChE
  3. Ajmalicine

Ajmalicine (Synonyms: Raubasine)

Cat. No.: HY-N1919
Handling Instructions

Ajmalicine (Raubasine) is found in herbs of Catharanthus roseus, is an antihypertensive drug used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure. Ajmalicine (Raubasine) is an adrenolytic drug which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor. Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM. Ajmalicine (Raubasine) acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.

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Ajmalicine Chemical Structure

Ajmalicine Chemical Structure

CAS No. : 483-04-5

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Description

Ajmalicine (Raubasine) is found in herbs of Catharanthus roseus, is an antihypertensive drug used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure[1]. Ajmalicine (Raubasine) is an adrenolytic drug which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor[2]. Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM[3]. Ajmalicine (Raubasine) acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[4].

Molecular Weight

352.43

Formula

C₂₁H₂₄N₂O₃

CAS No.

483-04-5

SMILES

O=C(C1=CO[[email protected]@H](C)[[email protected]](CN2CC3)([H])[[email protected]]1([H])C[[email protected]@]2([H])C4=C3C5=CC=CC=C5N4)OC

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Ajmalicine
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