1. GPCR/G Protein
  2. Adenosine Receptor
  3. PD 117519

PD 117519 (Synonyms: CI947)

Cat. No.: HY-100032 Purity: 99.94%
Handling Instructions

PD 117519 (CI947) is an A2A adenosine agonist which has shown oral antihypertensive activity in pharmacological animal models.

For research use only. We do not sell to patients.

PD 117519 Chemical Structure

PD 117519 Chemical Structure

CAS No. : 96392-15-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 372 In-stock
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100 mg USD 660 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

PD 117519 (CI947) is an A2A adenosine agonist which has shown oral antihypertensive activity in pharmacological animal models[1][2].

IC50 & Target

A2A adenosine[1]

In Vivo

PD 117519 (2-10 mg/kg; oral administration; 16-24 hours; male beagle dogs) treatment produces significant hemodynamic changes at Tmax (4 hours) follows by acute coronary vascular injury that is evident at 16 hours postdosing.Treatment with 2 or 10 mg/kg of PD 117519 produces significant increases in mean heart rate and decreases in mean indirectsystolic blood pressure at time of highest drug exposure, 4 hours postdosing[3].

Animal Model: 24 male beagle dogs (8-12 months old)[3]
Dosage: 2 mg/kg or 10 mg/kg
Administration: Oral administration; 16 hours and 24 hours
Result: Increased in mean heart rate and decreased in mean indirectsystolic blood pressure at time of highest drug exposure. Induced acute coronary arteriopathy. The endothelium also appears injured.
Molecular Weight

383.40

Formula

C₁₉H₂₁N₅O₄

CAS No.

96392-15-3

SMILES

OC[[email protected]@H]1[[email protected]]([[email protected]]([[email protected]](N2C=NC3=C2N=CN=C3N[[email protected]@H]4CCC5=C4C=CC=C5)O1)O)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (260.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6082 mL 13.0412 mL 26.0824 mL
5 mM 0.5216 mL 2.6082 mL 5.2165 mL
10 mM 0.2608 mL 1.3041 mL 2.6082 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
PD 117519
Cat. No.:
HY-100032
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