1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Dihydroergotoxine mesylate

Dihydroergotoxine mesylate (Synonyms: Ergoloid mesylates)

Cat. No.: HY-B0799 Purity: ≥98.0%
Handling Instructions

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site.

For research use only. We do not sell to patients.

Dihydroergotoxine mesylate Chemical Structure

Dihydroergotoxine mesylate Chemical Structure

CAS No. : 8067-24-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 119 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 108 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. IC50 value: Target: Dihydroergotoxine mesylate also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Dihydroergotoxine mesylate displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo.

Clinical Trial
Molecular Weight

2314.74

Formula

C123H156N20O23S

CAS No.
SMILES

CN1C[[email protected]](C(N[[email protected]@]2(C)C(N([[email protected]@H](CC(C)C)C(N3[[email protected]@]4([H])CCC3)=O)[[email protected]@]4(O)O2)=O)=O)CC([[email protected]@]1([H])C5)C6=CC=CC7=C6C5=CN7.CN8C[[email protected]](C(N[[email protected]@]9(C)C(N([[email protected]@H](C(C)C)C(N%10[[email protected]@]%11([H])CCC%10)=O)[[email protected]@]%11(O)O9)=O)=O)CC([[email protected]@]8([H])C%12)C%13=CC=CC%14=C%13C%12=CN%14.CN%15C[[email protected]](C(N[[email protected]@]%16(C)C(N([[email protected]@H]([[email protected]](CC)C)C(N%17[[email protected]@]%18([H])CCC%17)=O)[[email protected]@]%18(O)O%16)=O)=O)CC([[email protected]@]%15([H])C%19)C%20=CC=CC%21=C%20C%19=CN%21.CN%22C[[email protected]](C(N[[email protected]@]%23(C)C(N([[email protected]@H](CC%24=CC=CC=C%24)C(N%25[[email protected]@]%26([H])CCC%25)=O)[[email protected]@]%26(O)O%23)=O)=O)CC([[email protected]@]%22([H])C%27)C%28=CC=CC%29=C%28C%27=CN%29.CS(O)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (43.20 mM)

H2O : 2 mg/mL (0.86 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4320 mL 2.1601 mL 4.3201 mL
5 mM 0.0864 mL 0.4320 mL 0.8640 mL
10 mM 0.0432 mL 0.2160 mL 0.4320 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (0.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (0.90 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (0.90 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: ≥98.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Dihydroergotoxine mesylate
Cat. No.:
HY-B0799
Quantity:
MCE Japan Authorized Agent: