Brefonalol (hydrochloride)  (Synonyms: Brefanolol (hydrochloride))

Brefonalol (Brefanolol) hydrochloride is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties. Brefonalol hydrochloride exhibits an optimal balance between β-blockade and vasodilatory effects at low doses: it reduces blood pressure and slows heart rate, while increasing stroke volume instead of decreasing it, causing no significant elevation in peripheral resistance and increasing reactive hyperemia; at high doses, the β-blockade effect dominates. Brefonalol hydrochloride can be used in the research of arterial hypertension^[1].

Brefonalol hydrochloride exhibits balanced β-receptor blocking and vasodilatory effects at a dose of 50 mg, while at a dose of 100 mg, it primarily exerts β-receptor blocking effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

388.93

C₂₂H₂₉ClN₂O₂

3026677-28-8

Solid

O=C1NC2=C(C=C(C(O)CNC(C)(C)CCC3=CC=CC=C3)C=C2)CC1.Cl

Room temperature in continental US; may vary elsewhere.

• [1]. Halabi A, et al. Hemodynamic effects of brefanolol and propranolol assessed by noninvasive methods in patients with arterial hypertension. J Cardiovasc Pharmacol. 1990;16(1):81-86.  [Content Brief]