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Muzolimine  (Synonyms: BAY-g 2821; Edrul)

Cat. No.: HY-106616 Purity: 99.57%
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Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive effects. Muzolimine can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Muzolimine Chemical Structure

Muzolimine Chemical Structure

CAS No. : 55294-15-0

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10 mM * 1 mL in DMSO
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Solid
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Based on 1 publication(s) in Google Scholar

Muzolimine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive effects. Muzolimine can be used for the research of cardiovascular disease[1][2].

In Vitro

Muzolimine (10 μM-1 mM) dose-dependently inhibits ion transport in Ehrlich cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Muzolimine Related Antibodies
In Vivo

Muzolimine (0-18 mg/kg; p.o. 7-times per week for 3 months) shows a marked diuresis effect in dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3 male and 3 female dogs[1]
Dosage: 0, 2, 6, 8 and 18 mg/kg
Administration: Oral gavage; 7 times per week for 3 months
Result: Showed significant diuretic results, and increased the water intake of dogs.
Molecular Weight

272.13

Formula

C11H11Cl2N3O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C1=CC(Cl)=C(Cl)C=C1)N2C(CC(N)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (367.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6747 mL 18.3736 mL 36.7471 mL
5 mM 0.7349 mL 3.6747 mL 7.3494 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6747 mL 18.3736 mL 36.7471 mL 91.8679 mL
5 mM 0.7349 mL 3.6747 mL 7.3494 mL 18.3736 mL
10 mM 0.3675 mL 1.8374 mL 3.6747 mL 9.1868 mL
15 mM 0.2450 mL 1.2249 mL 2.4498 mL 6.1245 mL
20 mM 0.1837 mL 0.9187 mL 1.8374 mL 4.5934 mL
25 mM 0.1470 mL 0.7349 mL 1.4699 mL 3.6747 mL
30 mM 0.1225 mL 0.6125 mL 1.2249 mL 3.0623 mL
40 mM 0.0919 mL 0.4593 mL 0.9187 mL 2.2967 mL
50 mM 0.0735 mL 0.3675 mL 0.7349 mL 1.8374 mL
60 mM 0.0612 mL 0.3062 mL 0.6125 mL 1.5311 mL
80 mM 0.0459 mL 0.2297 mL 0.4593 mL 1.1483 mL
100 mM 0.0367 mL 0.1837 mL 0.3675 mL 0.9187 mL
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Muzolimine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muzolimine55294-15-0BAY-g 2821 EdrulOthersdiuresisHenle loopanti-hypertensivecardiovascular diseasedogwaterInhibitorinhibitorinhibit

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