AT1R antagonist 3
AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV1.2 (IC50=0.57 μM). AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models.
For research use only. We do not sell to patients.
- CAS No.: 3053482-15-5
- Formula: C22H16N6O2S
- Molecular Weight:428.47
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
|
Cav1.2 0.57 μM (Ki) |
Chemical Information
-
CAS No. 3053482-15-5
-
Molecular Weight 428.47
-
Formula C22H16N6O2S
-
SMILES
O=C(C1=CC2=C(NC(SCC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=N2)C=C1)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AT1R antagonist 3 Related Classifications
HY-159090 Related Classifications
Powered by Bioz