1. Anti-infection
  2. SARS-CoV
  3. Cleistanthin B

Cleistanthin B (Synonyms: Diphyllin O-glucoside)

Cat. No.: HY-N9351
Handling Instructions

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo.

For research use only. We do not sell to patients.

Cleistanthin B Chemical Structure

Cleistanthin B Chemical Structure

CAS No. : 30021-77-3

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Description

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

IC50 & Target

IC50: 6.51 µM (SARS-CoV-2)[1]

In Vitro

Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1].
Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

542.49

Formula

C₂₇H₂₆O₁₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Cleistanthin B
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