2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Adrenergic Receptor 5-HT Receptor Histamine Receptor
  4. Atiprosine

Atiprosine (AY-28228) is an orally effective selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. Atiprosine exhibits antagonistic activity against α2-adrenergic receptors (α1-adrenergic receptor), 5-HT₂ receptors (5-HT₂ receptor), and H₁ receptors (H₁ receptor). The pA2 values for these receptors are 6.04, 6.87, and 7.32 respectively. Atiprosine has antihypertensive and hypotensive effects in rats, dogs, and monkeys. It can be used for research on cardiovascular and mental disorders.

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Atiprosine

Atiprosine Chemical Structure

CAS No. : 89303-63-9

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Atiprosine Related Antibodies

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α adrenergic receptor β adrenergic receptor

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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Description

Atiprosine (AY-28228) is an orally effective selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. Atiprosine exhibits antagonistic activity against α2-adrenergic receptors (α1-adrenergic receptor), 5-HT₂ receptors (5-HT₂ receptor), and H₁ receptors (H₁ receptor). The pA2 values for these receptors are 6.04, 6.87, and 7.32 respectively. Atiprosine has antihypertensive and hypotensive effects in rats, dogs, and monkeys. It can be used for research on cardiovascular and mental disorders.

IC50 & Target>[2]

α1-adrenergic receptor

8.11 (pA2)

α2-adrenergic receptor

6.04 (pA2)

5-HT2 Receptor

6.87 (pA2)

H1 Receptor

7.32 (pA2)

Molecular Weight

311.46

Formula

C20H29N3
CAS No.
SMILES

CC(C)N1CCN([C@@]2([C@@]1(CCN3C2=C(C4=C3C=CC=C4)C)[H])[H])CC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Atiprosine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atiprosine89303-63-9AY-28228AY28228AY 28228Adrenergic Receptor5-HT ReceptorHistamine ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptoralpha-1 adrenoceptor antagonistpA2 valuereceptor selectivityketanserinindoramin5-HT2 receptorhistamine H1 receptorvascular smooth muscleInhibitorinhibitorinhibit

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