Atiprosine
Atiprosine (AY-28228) is an orally effective selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. Atiprosine exhibits antagonistic activity against α2-adrenergic receptors (α1-adrenergic receptor), 5-HT₂ receptors (5-HT₂ receptor), and H₁ receptors (H₁ receptor). The pA2 values for these receptors are 6.04, 6.87, and 7.32 respectively. Atiprosine has antihypertensive and hypotensive effects in rats, dogs, and monkeys. It can be used for research on cardiovascular and mental disorders.
For research use only. We do not sell to patients.
- CAS No.: 89303-63-9
- Formula: C20H29N3
- Molecular Weight:311.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
MoreAll 5-HT Receptor Isoforms
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Biological Activity
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α1-adrenergic receptor 8.11 (pA2) |
α2-adrenergic receptor 6.04 (pA2) |
5-HT2 Receptor 6.87 (pA2) |
H1 Receptor 7.32 (pA2) |
Chemical Information
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CAS No. 89303-63-9
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Molecular Weight 311.46
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Formula C20H29N3
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SMILES
CC(C)N1CCN([C@@]2([C@@]1(CCN3C2=C(C4=C3C=CC=C4)C)[H])[H])CC
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Synonyms
AY-28228
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Oshiro G, et al. Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys. J Cardiovasc Pharmacol. 1987 Sep;10(3):341-9. [Content Brief]
[2]. Grimes D, et al. In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound. J Cardiovasc Pharmacol. 1987 Sep;10(3):249-58. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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