1. Metabolic Enzyme/Protease
    Apoptosis
  2. Angiotensin-converting Enzyme (ACE)
    Apoptosis
  3. Moexipril hydrochloride

Moexipril hydrochloride (Synonyms: RS-10085)

Cat. No.: HY-B0378A Purity: 98.49%
Handling Instructions

Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure.

For research use only. We do not sell to patients.

Moexipril hydrochloride Chemical Structure

Moexipril hydrochloride Chemical Structure

CAS No. : 82586-52-5

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10 mM * 1  mL in DMSO USD 55 In-stock
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Description

Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure. Target: ACE Moexipril hydrochloride is a long-acting ACE inhibitor suitable for once-daily administration, and like some ACE inhibitors, moexipril is a prodrug and needs to be hydrolyzed in the liver into its active carboxylic metabolite, moexiprilat, to become effective [1]. Upon oral administration of moexipril (10 mg/kg/day) to spontaneously hypertensive rats, plasma angiotensin II concentration decreased to undetectable levels, plasma ACE activity was inhibited by 98% and plasma angiotensin I concentration increased 8.6-fold 1 h after dosing. At 24 h, plasma angiotensin I and angiotensin II concentrations had returned to pretreatment levels, whereas plasma ACE activity was still inhibited by 56%. Four-week oral administration of moexipril (0.1-30 mg/kg/day) to spontaneously hypertensive rats lowered blood pressure and differentially inhibited ACE activity in plasma, lung, aorta, heart and kidney in a dose-dependent fashion [2, 3].

Clinical Trial
Molecular Weight

535.03

Formula

C₂₇H₃₅ClN₂O₇

CAS No.

82586-52-5

SMILES

O=C([[email protected]]1N(C([[email protected]@H](N[[email protected]](C(OCC)=O)CCC2=CC=CC=C2)C)=O)CC3=C(C=C(OC)C(OC)=C3)C1)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (186.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8691 mL 9.3453 mL 18.6905 mL
5 mM 0.3738 mL 1.8691 mL 3.7381 mL
10 mM 0.1869 mL 0.9345 mL 1.8691 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.5 mg/mL (6.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.5 mg/mL (6.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.5 mg/mL (6.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MoexiprilRS-10085RS10085RS 10085Angiotensin-converting Enzyme (ACE)ApoptosisInhibitorinhibitorinhibit

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Moexipril hydrochloride
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