1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Celiprolol hydrochloride

Celiprolol hydrochloride 

Cat. No.: HY-B1264
Handling Instructions

Celiprolol hydrochloride is a potent, selective and orally active antagonist of β1-andrenoceptor with partial β2 agonist activity, therefore it is a selective adrenoreceptor modulator (SAM). Celiprolol hydrochloride demonstrates antihypertensive and antianginal activity.

For research use only. We do not sell to patients.

Celiprolol hydrochloride Chemical Structure

Celiprolol hydrochloride Chemical Structure

CAS No. : 57470-78-7

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Description

Celiprolol hydrochloride is a potent, selective and orally active antagonist of β1-andrenoceptor with partial β2 agonist activity, therefore it is a selective adrenoreceptor modulator (SAM). Celiprolol hydrochloride demonstrates antihypertensive and antianginal activity[1].

IC50 & Target

β1-andrenoceptor[1]

In Vivo

Celiprolol (5 or 50 mg/kg; p.o. every day for 12 weeks) has a moderate antihypertensive action at the dose of 50 mg/kg, and significantly reduces media smooth muscle hypertrophy of the mesenteric artery in SHR[2].

Animal Model: Male spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats (8 weeks old)[2]
Dosage: 5, 50 mg/kg
Administration: P.o. every day (administered in drinking water) for 12 weeks
Result: Attenuated the rise in blood pressure significantly at the dose of 50 mg/kg in SHR.
Did not significantly affect absolute heart or body weights.
Reduced the average medial thickness of the mesenteric artery in SHR.
Molecular Weight

415.95

Formula

C₂₀H₃₄ClN₃O₄

CAS No.

57470-78-7

SMILES

O=C(NC1=CC=C(OCC(O)CNC(C)(C)C)C(C(C)=O)=C1)N(CC)CC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CeliprololAdrenergic ReceptorBeta Receptorβ1andrenoceptorpartialβ2adrenoreceptormodulatorSAMantihypertensiveantianginalInhibitorinhibitorinhibit

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Celiprolol hydrochloride
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