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Cat. No.: HY-114424

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H-Ile-Pro-Pro-OH

Name: H-Ile-Pro-Pro-OH
Brand: MedChemExpress
SKU: HY-114424
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM. Antihypertensive tripeptides.

For research use only. We do not sell to patients.

CAS No.: 26001-32-1
Formula: C₁₆H₂₇N₃O₄
Molecular Weight:325.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

H-Ile-Pro-Pro-OH Chemical Structure

CAS No.: 26001-32-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

H-Ile-Pro-Pro-OH, a milk-derived peptide^[1], inhibits angiotensin-converting enzyme (ACE)^[1] with an IC₅₀ of 5 μM^[2]. Antihypertensive tripeptides^[1].

IC₅₀ & Target

IC50: 5 μM (ACE)^[2]

In Vitro

Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats^[1]
Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) ^[1].
Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 26001-32-1
Molecular Weight 325.40
Formula C₁₆H₂₇N₃O₄
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

J Physiol Biochem

Ile-Pro-Pro attenuates sympathetic activity and hypertension. [Abstract]

2024 Aug;80(3):585-598. PMID: 39008241

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7. [Content Brief]

[2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

H-Ile-Pro-Pro-OH

1 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Protocols
Purity & Documentation
References

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H-Ile-Pro-Pro-OH

Publications Citing Use of MedChemExpress (MCE) H-Ile-Pro-Pro-OH