1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. H-Ile-Pro-Pro-OH

H-Ile-Pro-Pro-OH 

Cat. No.: HY-114424
Handling Instructions

H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

H-Ile-Pro-Pro-OH Chemical Structure

H-Ile-Pro-Pro-OH Chemical Structure

CAS No. : 26001-32-1

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Description

H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

IC50 & Target

IC50: 5 μM (ACE)[2]

In Vitro

Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].

In Vivo

Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats[1]
Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) [1].
Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].

Molecular Weight

325.40

Formula

C₁₆H₂₇N₃O₄

CAS No.

26001-32-1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

H-Ile-Pro-Pro-OHAngiotensin-converting Enzyme (ACE)milk-derivedAntihypertensivetripeptideInhibitorinhibitorinhibit

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H-Ile-Pro-Pro-OH
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