1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)

H-Ile-Pro-Pro-OH 

Cat. No.: HY-114424
Handling Instructions

H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

H-Ile-Pro-Pro-OH Chemical Structure

H-Ile-Pro-Pro-OH Chemical Structure

CAS No. : 26001-32-1

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

IC50 & Target

IC50: 5 μM (ACE)[2]

In Vitro

Vitro: Ile-Pro-Pro (IPP) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].

In Vivo

Vivo: Ile-Pro-Pro attenuates arterial dysfunction in L-NAME-treated rats[1]
Ile-Pro-Pro (IPP) decreases blood pressure in spontaneously hypertensive rats (SHR) [1].
Ile-Pro-Pro (IPP) attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0731 mL 15.3657 mL 30.7314 mL
5 mM 0.6146 mL 3.0731 mL 6.1463 mL
10 mM 0.3073 mL 1.5366 mL 3.0731 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

325.40

Formula

C₁₆H₂₇N₃O₄

CAS No.

26001-32-1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
H-Ile-Pro-Pro-OH
Cat. No.:
HY-114424
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H-Ile-Pro-Pro-OH

Cat. No.: HY-114424