1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. LY-272015 hydrochloride

LY-272015 hydrochloride 

Cat. No.: HY-100851A Purity: 99.54%
COA Handling Instructions

LY-272015 hydrochloride is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats.

For research use only. We do not sell to patients.

LY-272015 hydrochloride Chemical Structure

LY-272015 hydrochloride Chemical Structure

CAS No. : 172895-15-7

Size Price Stock Quantity
5 mg USD 160 In-stock
10 mg USD 256 In-stock
25 mg USD 538 In-stock
50 mg USD 860 In-stock
100 mg USD 1380 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

LY-272015 hydrochloride is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats[1][2].

IC50 & Target[1]

5-HT2B Receptor

 

Molecular Weight

372.89

Formula

C21H25ClN2O2

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=CC2=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.41 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6818 mL 13.4088 mL 26.8176 mL
5 mM 0.5364 mL 2.6818 mL 5.3635 mL
10 mM 0.2682 mL 1.3409 mL 2.6818 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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LY-272015 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
LY-272015 hydrochloride
Cat. No.:
HY-100851A
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