Enalapril sodium
Based on 1 Customer Validation
Enalapril (MK-421) sodium is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research.
For research use only. We do not sell to patients.
- CAS No.: 149404-21-7
- Formula: C20H27N2NaO5
- Molecular Weight:398.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Enalapril sodium
More- Nat Commun. 2023 May 2;14(1):2523. [Abstract]
- Elife. 2025 Aug 28:14:RP104774. [Abstract]
- Toxicol Appl Pharmacol. 2026 Mar 27:511:117802. [Abstract]
- Ren Fail. 2023;45(2):2253924. [Abstract]
- Am J Transl Res. 2022 Jan 15;14(1):211-222. [Abstract]
- Int J Clin Exp Pathol. 2020 May 1;13(5):827-836. [Abstract]
Biological Activity
Enalapril sodium (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity[1]. Enalapril sodium (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer's disease (AD) serum[2]. Pure Enalapril sodium has better thermal stability than pure Enalapril[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human umbilical vein ECs (HUVECs)
-
Concentration:50 μM
-
Incubation Time:24 hours
-
Result:Inhibited the induction of apoptosis by patient serum.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male NMRI mice 20-40 g[4]
-
Dosage:0.03 mg/kg
-
Administration:Intraperitoneal injection; once
-
Result:Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 149404-21-7
-
Molecular Weight 398.43
-
Formula C20H27N2NaO5
-
SMILES
O=C(O[Na])[C@H]1N(C([C@H](C)N[C@H](C(OCC)=O)CCC2=CC=CC=C2)=O)CCC1
-
Synonyms
MK-421 sodium
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [Abstract]2023 May 2;14(1):2523. PMID: 37130842 -
Elife
Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes. [Abstract]2025 Aug 28:14:RP104774. PMID: 40874922 -
Toxicol Appl Pharmacol
Saikosaponin D protects against isoproterenol-induced kidney injury in rats by regulating the intrarenal renin-angiotensin system. [Abstract]2026 Mar 27:511:117802. PMID: 41903810 -
Ren Fail
Crocin improves the renal autophagy in rat experimental membranous nephropathy via regulating the SIRT1/Nrf2/HO-1 signaling pathway. [Abstract]2023;45(2):2253924. PMID: 37724538 -
Am J Transl Res
Combination therapy with artemether and enalapril improves type 1 diabetic nephropathy through enhancing antioxidant defense. [Abstract]2022 Jan 15;14(1):211-222. PMID: 35173839 -
Int J Clin Exp Pathol
2020 May 1;13(5):827-836. PMID: 32509053
Purity & Documentation
References
[1]. Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22(6):698-705. [Content Brief]
[2]. Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer's disease. J Res Med Sci. 2013 Mar;18(Suppl 1):S1-5. [Content Brief]
[3]. Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14(3):1150-7. [Content Brief]
[4]. A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373(1):21-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz