1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Enalapril sodium

Enalapril sodium (Synonyms: MK-421 sodium)

Cat. No.: HY-B0331B
Handling Instructions

Enalapril (MK-421) sodium is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research.

For research use only. We do not sell to patients.

Enalapril sodium Chemical Structure

Enalapril sodium Chemical Structure

CAS No. : 149404-21-7

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Description

Enalapril (MK-421) sodium is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].

In Vitro

Enalapril sodium (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity[1].
Enalapril sodium (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer's disease (AD) serum[2].
Pure Enalapril sodium has better thermal stability than pure Enalapril[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Human umbilical vein ECs (HUVECs)
Concentration: 50 μM
Incubation Time: 24 hours
Result: Inhibited the induction of apoptosis by patient serum.
In Vivo

Enalapril sodium (intraperitoneal injection, 0.03 mg/kg, once) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI mice 20-40 g[4]
Dosage: 0.03 mg/kg
Administration: Intraperitoneal injection; once
Result: Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.
Molecular Weight

398.43

Formula

C20H27N2NaO5

CAS No.
SMILES

O=C(O[Na])[[email protected]]1N(C([[email protected]](C)N[[email protected]](C(OCC)=O)CCC2=CC=CC=C2)=O)CCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Enalapril sodium
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HY-B0331B
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