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Results for "

2-Alkenal reductase (NADP )

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (2) Aldose Reductase (42) Dihydrofolate reductase (DHFR) (23) Glutathione Reductase (GR) (5) GSNOR (4) HMG-CoA Reductase (HMGCR) (21) Quinone Reductase (3) TrxR (20) VKOR (1) 17β-HSD (2) Acetyl-CoA Carboxylase (2) ACSL Family (1) ADC Payloads (5) Adenosine Receptor (1) Akt (1) Aldehyde Dehydrogenase (ALDH) (1) Amino acid Transporter (1) Antibiotic (13) Antifolate (30) Apoptosis (41) Atg8/LC3 (1) Autophagy (16) Bacterial (47) Bcl-2 Family (2) Beclin1 (1) Biochemical Assay Reagents (32) Calcineurin (1) Calcium Channel (6) Caspase (5) CDK (1) CFTR (2) COX (4) Cytochrome P450 (8) DNA Alkylator/Crosslinker (4) DNA/RNA Synthesis (19) Drug Derivative (8) Drug Intermediate (6) Drug Metabolite (10) EBV (1) EGFR (1) Endogenous Metabolite (35) Environmental Pollutants (5) Farnesyl Transferase (3) Ferroptosis (10) Fluorescent Dye (6) Fungal (10) FXR (1) Glutamate Dehydrogenase (GLDH) (3) Glutathione Peroxidase (3) Glycosidase (2) HBV (1) HCV (3) Herbicide (1) HIV Protease (2) HSV (1) IDE (1) IFNAR (1) Influenza Virus (5) Interleukin Related (1) Isocitrate Dehydrogenase (IDH) (6) Isotope-Labeled Compounds (2) JAK (1) JNK (1) Keap1-Nrf2 (1) Lactate Dehydrogenase (2) Ligands for E3 Ligase (1) Lipoxygenase (1) MDM-2/p53 (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Microtubule/Tubulin (3) Mitochondrial Metabolism (4) Mitosis (1) mTOR (1) Na+/K+ ATPase (1) NADPH Oxidase (3) Necroptosis (1) NF-κB (3) NO Synthase (1) Nucleoside Antimetabolite/Analog (5) Opioid Receptor (1) Oxidative Phosphorylation (2) p38 MAPK (4) p62 (1) Parasite (14) PDI (1) PGE synthase (1) Phosphodiesterase (PDE) (1) Photosystem II (1) PI3K (1) PKC (1) Prostaglandin Receptor (2) PROTACs (3) Proteolytic Enzyme (1) Ras (1) Reactive Oxygen Species (ROS) (27) Reference Standards (31) SARS-CoV (1) Serotonin Transporter (1) SHMT (1) SOD (2) STAT (3) Succinate Dehydrogenase (1) Thymidylate Synthase (2) TNF Receptor (1) Tyrosinase (1) Virus Protease (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (127) Cardiovascular Disease (25) Endocrinology (9) Infection (78) Inflammation/Immunology (48) Metabolic Disease (105) Neurological Disease (25)
Click Chemistry:	Azide (1) Alkynes (2)
Oligonucleotides:	Nucleotide Analogs (3)

354

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: Quinone Reductase 5 alpha Reductase Carbonyl Reductase Glutathione Reductase (GR) Aldose Reductase TrxR Dihydrofolate reductase (DHFR) HMG-CoA Reductase (HMGCR) GSNOR VKOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013046

Phosphoribosyl pyrophosphate pentasodium PRPP pentasodium	Endogenous Metabolite	Others
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .

HY-F0002

NADP sodium salt Maximum Cited Publications 6 Publications Verification Sodium NADP	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-W010342

6-Aminonicotinamide 15+ Cited Publications	NADPH Oxidase	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP ⁺-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells ^[2] .

HY-F0002A

NADP disodium salt Maximum Cited Publications 6 Publications Verification Disodium NADP	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-113325

*NADP* Maximum Cited Publications 6 Publications Verification	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-123962

G6PD activator AG1 5+ Cited Publications	NADPH Oxidase	Metabolic Disease
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes ^[2].

HY-113325A

NADP sodium hydrate 5+ Cited Publications	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-P2947

ALDH Aldehyde dehydrogenase (NAD(P))	Aldehyde Dehydrogenase (ALDH)	Others Cancer
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .

HY-150621

AS1134900	β-catenin Wnt	Cancer
AS1134900 is a highly selective uncompetitive allosteric inhibitor of NADP ⁺-dependent malic enzyme 1 (ME1) with an IC₅₀ of 0.73 μM. AS1134900 can be used in the study of cancer .

HY-108251

Methotrexate metabolite 1 Publications Verification DAMPA	Antifolate Drug Metabolite Dihydrofolate reductase (DHFR) Parasite	Infection Inflammation/Immunology
Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid (HY-16637) antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC₅₀ values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate metabolite exhibits pharmacokinetic characteristics of rapid clearance and extensive metabolism, with a mean clearance rate of 1.9 l/kg/h and a mean terminal half-life of 51 minutes. Methotrexate metabolite is promising for research in the field of inflammation ^[2] .

HY-N0352

Tuberostemonine 1 Publications Verification	Parasite	Infection
Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent ^[2] .

HY-P2897

D-Lactate dehydrogenase, Microorganism 1 Publications Verification D-LDH	Lactate Dehydrogenase	Others
D-Lactate dehydrogenase, Microorganism (D-LDH) is an oxidoreductase that uses NAD ⁺ or NADP ⁺ as an acceptor and acts on the donor CH-OH group, and can catalyze the oxidation of D-lactate to pyruvate. D-Lactate dehydrogenase widely exists in bacteria and fungi, and is often used in biochemical research .

HY-117570

KSC-34	PDI	Neurological Disease
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC₅₀ of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family . KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P2911

*Glutamate dehydrogenase (NAD(P))* GLDH	Mitochondrial Metabolism	Others
Glutamate dehydrogenase NAD(P) (GLDH) can be found in hepatocytes, renal tissue, brain, muscle, and intestinal cells. Glutamate dehydrogenase NAD(P) is often used in biochemical studies. Glutamate dehydrogenase is a mitochondrial enzyme, it catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG) as part of the urea cycle .

HY-P3186

Glucose dehydrogenase, recombinant Microorganisms	Endogenous Metabolite	Metabolic Disease
Glucose dehydrogenase, recombinant Microorganisms is a FDA-dependent oxidoreductase. Glucose dehydrogenase (GDH) catalyzes the oxidation of β-D-glucose to β-D-glucono-1,5-lactone with simultaneous reduction of the cofactor NADP ⁺ to NADPH or, to a lesser extent, NAD ⁺ to NADH. Glucose dehydrogenase (GDH) accepts both NAD ⁺ and NADP ⁺ as cofactors and can be used for the regeneration of NADH and NADPH ^[2].

HY-131521

Oxalomalic acid trisodium Oxalomalate trisodium	Isocitrate Dehydrogenase (IDH)	Cancer
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .

HY-154924

Thio-NADP S-NADP	Calcium Channel	Cardiovascular Disease
Thio-NADP (S-NADP) is a nicotinic acid adenine dinucleotide phosphate (NAADP) inhibitor. Thio-NADP activates partial Ca ²⁺ release .

HY-113325AR

NADP sodium hydrate (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease Inflammation/Immunology Cancer
NADP sodium hydrate (Standard) is the analytical standard of NADP sodium hydrate (HY-113325A). This product is intended for research and analytical applications. NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

HY-W003561

DHFR-IN-3	Antifolate Parasite	Infection
DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC₅₀ values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively .

HY-124350

10-Formylfolic acid	Antifolate Dihydrofolate reductase (DHFR)	Cancer
10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia ^[2].

HY-F0002R

NADP sodium salt (Standard) Sodium NADP (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease Inflammation/Immunology Cancer
NADP (sodium salt) (Standard) is the analytical standard of NADP (sodium salt). This product is intended for research and analytical applications. NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4].

HY-137672A

*2',3'-Cyclic NADP* disodium** 2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate	Phosphodiesterase (PDE) Calcium Channel	Neurological Disease
2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.

HY-118588

Diminutol	Quinone Reductase Microtubule/Tubulin	Others
Diminutol is an inhibitor for NADP-dependent quinone oxidoreductase (NQO1), that is involved in microtubule morphogenesis and cell devision .

HY-W052512

Antitrypanosomal agent 1	Parasite	Infection
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC₅₀ of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC₅₀=64.8 μM) and T. brucei (EC₅₀=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity .

HY-W157689

IDE-IN-2 1 Publications Verification	Proteolytic Enzyme IDE	Infection Metabolic Disease Cancer
IDE-IN-2 (Compound 4) is an inhibitor for insulin-degrading enzyme. IDE-IN-2 is predicted to have CYP3A4, CYP2C19, hERG, NADP+, HIF1α and histidine kinase inhibitory activities, and has potential biological activity in anti-diabetic, anti-tumor, anti-bacterial aspects, according to the in silico prediction .

HY-P2944

*Ferredoxin-NADP* reductase**	Biochemical Assay Reagents	Metabolic Disease
Ferredoxin-NADP reductase in plants receives electrons from ferredoxin (Fd) at the end of the photosynthetic electron transfer chain and converts NADP ⁺ to NADPH .

HY-P2912

*Glutamate dehydrogenase (NADP)*	Glutamate Dehydrogenase (GLDH) Biochemical Assay Reagents	Neurological Disease
Glutamate dehydrogenase (NADP) is the catalytic enzyme for glutamate production. Dysfunction of Glutamate dehydrogenase (NADP) may induce various neurodegenerative diseases, such as Parkinson's disease, epilepsy, Alzheimer's disease, schizophrenia, and frontotemporal dementia. Glutamate dehydrogenase (NADP) can be used in research on neurological diseases such as Parkinson's disease, epilepsy, and Alzheimer's disease .

HY-P2740B

Alcohol dehydrogenase, yeast	Endogenous Metabolite	Metabolic Disease
Alcohol dehydrogenase, yeast is an alcohol dehydrogenase expressed in yeast. It can catalyze the conversion between ethanol and acetaldehyde, while also reducing NAD or NADP, and it plays a role in glycolysis and aerobic respiration .

HY-P2993

Isocitrate dehydrogenase, Porcine heart ICDH; IDH	Isocitrate Dehydrogenase (IDH)	Metabolic Disease Cancer
Isocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) ⁺ to NAD(P)H, it plays important roles in cellular metabolism .

HY-E70406

Cholesterol Dehydrogenase, Nocardia sp. CHDH-5	Endogenous Metabolite	Others
Cholesterol Dehydrogenase, Nocardia sp. is an enzyme that uses nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NAD(P)) as its cofactor in oxidizing cholesterol to form cholest-4-en-3-one. This enzyme oxidizes the hydroxyl group at the 3 position of the sterol ring to form a ketone.

HY-108534

PMX464 AW 464	TrxR	Inflammation/Immunology Cancer
PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells .

HY-P3001

*Malate dehydrogenase oxaloacetate-decarboxylating, NADP+*	Endogenous Metabolite	Metabolic Disease
Malate dehydrogenase (oxaloacetate-decarboxylating, NADP+) is a redox agent targeting metabolic pathways. Malate dehydrogenase (oxaloacetate-decarboxylating, NADP+) catalyzes the reduction of oxaloacetate to malate in leaves of higher plants. Malate dehydrogenase (oxaloacetate-decarboxylating, NADP+) is promising for research of metabolic diseases, such as diabetes, obesity .

HY-125863A

Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) G6PD (Leuconostoc sp., recombinant)	Endogenous Metabolite	Metabolic Disease
Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) is an NADP-dependent enzyme in the pentose phosphate pathway, which is one of the ways glucose is metabolized. Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) can be used to quantify ATP, glucose, and creatine kinase .

HY-135402

2'-Ethyl Simvastatin	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Cancer
2'-Ethyl Simvastatin (compound 6) is a Mevinolin analog, with HMG-CoA reductase inhibition .

HY-111008A

Trimidox hydrochloride VF-233 hydrochloride	DNA/RNA Synthesis	Cancer
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-E71466

2-Alkenal reductase (NADP+)

HY-E71466A

2-Alkenal reductase [NAD(P)+]

HY-P3175

*Phosphogluconate dehydrogenase (NADP, decarboxylating)* 6-Phosphogluconate dehydrogenase	Biochemical Assay Reagents	Metabolic Disease
Phosphogluconate dehydrogenase (NADP, decarboxylating) (6-Phosphogluconate dehydrogenase) is an oxidative carboxylase that catalyses the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate in the context of the oxidative part of the pentose phosphate pathway .

HY-N0352R

Tuberostemonine (Standard)	Reference Standards Parasite	Infection
Tuberostemonine (Standard) is the analytical standard of Tuberostemonine. This product is intended for research and analytical applications. Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine has a level of activity as a feeding deterrent ^[2].

HY-W010342R

6-Aminonicotinamide (Standard)	NADPH Oxidase Reference Standards	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells ^[2] .

HY-W319094

4′-Hydroxyflavone	Aldose Reductase
4′-Hydroxyflavone (compound 50) can inhibit aldose reductase, with IC₅₀ 12 μM .

HY-F0002AR

NADP disodium salt (Standard) Disodium NADP (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease Inflammation/Immunology Cancer
NADP (disodium salt) (Standard) is the analytical standard of NADP (disodium salt). This product is intended for research and analytical applications. NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-137593A

N6-Etheno-nicotinamide dinucleotide phosphate trisodium ε-NADP+ trisodium	Drug Derivative	Metabolic Disease
N6-Etheno-nicotinamide dinucleotide phosphate (ε-NADP+) trisodium, a structural analogue of the NADP(+), is a maize malic enzyme inhibitor with a K_i of 1.01 μM .

HY-138118

Propyl nicotinate Nicotinic acid propyl ester	Endogenous Metabolite	Others
Propyl nicotinate (Nicotinic acid propyl ester), the propyl ester of niacin, occurs in various animal and plant tissues, where it contributes to the formation of the coenzymes NAD and NADP.

HY-P2993A

Isocitrate dehydrogenase, Microorganism ICDH, Microorganism; IDH, Microorganism	Isocitrate Dehydrogenase (IDH)	Metabolic Disease
Isocitrate dehydrogenase, Microorganism (IDH) (EC 1.1.1.42) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) ⁺ to NAD(P)H, it plays important roles in cellular metabolism .

HY-N12472

Floramanoside C	Aldose Reductase	Others
Floramanoside C shows 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities .

HY-16152

Crilvastatin PMD 387	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Crilvastatin (PMD 387) is a potent inhibitor of HMG-CoA reductase .

HY-E70412

Galactose 1-dehydrogenase, E.coli	Endogenous Metabolite	Metabolic Disease
Galactose 1-dehydrogenase, E.coli is a dehydrogenase expressed in E. coli. Galactose 1-dehydrogenase, E.coli catalyzes the oxidation of L-arabinose and D-galactose using NADP ⁺/NAD ⁺ as cofactors. Galactose 1-dehydrogenase, E.coli can be used in diagnostic tests to determine total galactose content and can also serve as a biocatalyst for producing galacturonate .

HY-D1253

TP-TRFS	TrxR	Neurological Disease
TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR) .

HY-16166

Dalvastatin RG-12561	HMG-CoA Reductase (HMGCR)	Inflammation/Immunology
Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013046

Phosphoribosyl pyrophosphate pentasodium PRPP pentasodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .

HY-F0002A

NADP disodium salt Maximum Cited Publications 6 Publications Verification Disodium NADP	other families Microorganisms Classification of Application Fields Animals Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields Source Classification	Endogenous Metabolite
NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-14769

Folitixorin 2 Publications Verification 5,10-Methylenetetrafolate; ANX-510 free acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research ^[2].

HY-113342

7-Ketocholesterol 5 Publications Verification	Triterpenes Terpenoids Endogenous metabolite Source Classification	Endogenous Metabolite p38 MAPK
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-113325

*NADP* Maximum Cited Publications 6 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-N0033

Poliumoside Maximum Cited Publications 8 Publications Verification	Cardiovascular Disease Classification of Application Fields Callicarpa formosana Rolfe Plants Simple Phenylpropanols Verbenaceae Scrophulariaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Source Classification Brandisia hancei Hook. f.	Aldose Reductase
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity ^[2] .

HY-113325A

NADP sodium hydrate 5+ Cited Publications	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-W327449

Feruloylputrescine	Monophenols Gramineae Phenols Oryza sativa L. Plants Source Classification	Cytochrome P450
Feruloylputrescine is an oral active phenolamide found in citrus plants and formed through the decarboxylation of L-Arginine. Feruloylputrescine inhibits monooxygenase (cntA) and reductase (cntB) and trimethylamine production. Feruloylputrescine can be used for cardiovascular diseases research .

HY-126752

Ophthalmic acid	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reactive Oxygen Species (ROS)
Ophthalmic acid is a ubiquitous metabolite and glutathione modulator, with a K_i of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid is applicable in diabetes-related research ^[2].

HY-N2392

Kukoamine A 1 Publications Verification	Cardiovascular Disease Structural Classification Alkaloids other families Classification of Application Fields Other Alkaloids Phenols Polyphenols Plants Disease Research Fields Source Classification	Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX
Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, *PGE₂, TNF-α, IL-1β, IL-6* production and *COX-2* activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease ^[2] .

HY-N0468

Rebaudioside D 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Sweeteners Source Classification Food Research	FXR Acetyl-CoA Carboxylase
Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research ^[2].

HY-113355

NADH	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite Apoptosis
NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.

HY-N0864

Macranthoidin B Macranthoiside I	Structural Classification Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis COX Reactive Oxygen Species (ROS) Caspase SOD
Macranthoidin B (Macranthoiside I) is an orally active triterpene saponin. Macranthoidin B inhibits epithelial-mesenchymal transition in endometriosis via the *COX‑2/PGE2* pathway, and also induces tumor cell apoptosis and inhibits their proliferation by regulating metabolism and increasing ROS levels . Macranthoidin B can be used in studies related to endometriosis, colorectal cancer and hepatocellular carcinoma ^[2] .

HY-121362

Evernic Acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Disease Research Fields Inflammation/Immunology Source Classification	Bacterial Endogenous Metabolite TrxR
Evernic Acid is an orally active thioredoxin reductase 1 (TrxR1) inhibitor and antiproliferative agent. Evernic Acid inhibits the proliferation and migration of human breast cancer cells. Evernic Acid blocks the NF-κB pathway by inhibiting p65 nuclear translocation and IκBα phosphorylation, thereby suppressing downstream inflammatory mediators. Evernic Acid acts as an antioxidant, anti-inflammatory agent and neuroprotective agent, protects neurons from cell death, mitochondrial dysfunction and oxidative stress damage, reduces astrocyte activation, and ameliorates dopaminergic neuron loss and neuroinflammation. Evernic Acid inhibits enoyl reductases FabI and FabZ of Plasmodium falciparum. Evernic Acid downregulates the expression of lasB and rhlA genes in Pseudomonas aeruginosa, inhibits quorum sensing and biofilm formation, and exerts antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Evernic Acid is applicable to research related to breast cancer, Parkinson's disease, bacterial infections and fungal infections ^[2] .

HY-N0352

Tuberostemonine 1 Publications Verification	Infection Alkaloids other families Classification of Application Fields Pyrrole Alkaloids Plants Disease Research Fields Source Classification	Parasite
Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent ^[2] .

HY-N0913

Manninotriose 1 Publications Verification	Structural Classification other families Polysaccharides Classification of Application Fields Other Diseases Plants Disease Research Fields Saccharides Source Classification	Thymidylate Synthase Antifolate
Manninotriose is a natural functional trisaccharide composed of three mannose molecules. Manninotriose binds to dihydrofolate reductase via hydrogen bond formation with Arg28. Manninotriose binds to thymidylate synthase via hydrogen bond formation with Arg50. Manninotriose acts as a membrane protectant and helps improve stress tolerance. Manninotriose can be used in research related to acute lymphoblastic leukemia ^[2].

HY-113325AR

NADP sodium hydrate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
NADP sodium hydrate (Standard) is the analytical standard of NADP sodium hydrate (HY-113325A). This product is intended for research and analytical applications. NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

HY-169790

Phomarin	Plantaginaceae Digitalis purpurea L. Structural Classification Quinones Anthraquinones Plants Source Classification	Dihydrofolate reductase (DHFR) Parasite Fungal
Phomarin is an inhibitor for dihydrofolate reductase (DHFR). Phomarin exhibits activity against Plasmodium parasites and fungi including Mycrobotryum violaceum and Botrytis cinerea. Phomarin can be used for the research of malaria and fungal infections ^[2].

HY-135700

Mevalonolactone	Structural Classification Microorganisms Other Phenylpropanoids Phenylpropanoids Source Classification	Calcineurin Ras HMG-CoA Reductase (HMGCR)
Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (K_a = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy ^[2] .

HY-N9484

Menthofuran, 84%	Natural Products Classification of Application Fields Labiatae Other Diseases Erythrina poeppigiana Plants Disease Research Fields Source Classification	Drug Metabolite
Menthofuran is a proximate toxic metabolite of (R)-(+)-Pulegone. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase ^[2].

HY-129605

Ferulenol	Infection other families Classification of Application Fields Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Oxidative Phosphorylation Mitochondrial Metabolism
Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action ^[2] .

HY-122917

Danshenol A	Labiatae Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants	Aldose Reductase Reactive Oxygen Species (ROS)
Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC₅₀ of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research ^[2] .

HY-122439

Lovastatin acid Mevinolinic acid; MSD803	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	HMG-CoA Reductase (HMGCR) Drug Metabolite
Lovastatin acid (Mevinolinic acid; MSD803), an active metabolite of Lovastatin (HY-N0504), is a potent competitive HMG-CoA reductase inhibitor with a K_i of 0.6 nM. Lovastatin acid acts as a competitive inhibitor with respect to substrate HMG-CoA, interfering cholesterol synthesis. Lovastatin acid can be used for the research of hypercholesterolemia .

HY-137129

10-Formyl-7,8-dihydrofolic acid	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Dihydrofolate reductase (DHFR)
10-Formyl-7,8-dihydrofolic acid is a biologically active folic acid and growth promoter. 10-Formyl-7,8-dihydrofolic acid serves as a substrate for aminoimidazolecarboxamide ribonucleotide transformylase and dihydrofolate reductase (DHFR) to support catalytic reactions (with detection wavelengths of 552 nm and 340 nm, respectively). 10-Formyl-7,8-dihydrofolic acid not only promotes the growth of leukemia cells, but also effectively reverses the growth inhibition induced by antifolate drugs under folate-deficient conditions. 10-Formyl-7,8-dihydrofolic acid can be used in the research of leukemia .

HY-N0440R

Germacrone (Standard)	Structural Classification Terpenoids Sesquiterpenes Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 inﬂuenza A viruses and the inﬂuenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity ^[2] .

HY-N6243

Veratrosine	Cardiovascular Disease Structural Classification Veratrum nigrum Linn. Liliaceae Classification of Application Fields Plants Disease Research Fields Source Classification Steroids	Fungal
Veratrosine is a Trihydroxynapthalene reductase (THR) inhibitor and fungal plant pathogen inhibitor. Veratrosine interacts with THR, an enzyme in the DHN melanin biosynthesis pathway of Curvularia lunata. Veratrosine can be used for the research of leaf blight of rice, brown spot of rice, and blast disease of foxtail millet .

HY-113377

L-Glyceric acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2 ^[2].

HY-N9942

Physalin A 1 Publications Verification	Classification of Application Fields Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Ketones, Aldehydes, Acids Plants Solanaceae Disease Research Fields Source Classification Cancer	Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK
Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc ^[2] .

HY-122963

Danshenol B	Labiatae Terpenoids Artemisia austriaca Jacq. Diterpenoids Plants Source Classification	Adenosine Receptor
Danshenol B is a diterpenoid. Danshenol B has strong aldose reductase (AR) inhibitory activity with IC₅₀ value of 0.042μM. Danshenol B can be used for the research of diabetic related complication resulted by metabolic abnormality, such as cataracts, retinopathy, neuropathy, and nephropathy .

HY-N10184

Paecilaminol FKI-0550	Infection Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Others
Paecilaminol (FKI-0550) is potent NADH-fumarate reductase inhibitor. Paecilaminol exhibits an IC₅₀ value of 5.1 μM against Ascaris suum NADH-fumarate reductase .

HY-105629

Populin Salicin 6-benzoate; NSC 128308	Structural Classification Melicope bonwickii (F.Muell.) T.G.Hartley Plants Saccharides Source Classification Salicaceae Monosaccharides	Drug Derivative
Populin, a Salicin (HY-N0149) derivative, is a glucoside found in the fallen leaves of Populus alba × P. berolinensis .

HY-N16439

Phenicin Phoenicine	Structural Classification Quinones Microorganisms Benzene Quinones Source Classification	HMG-CoA Reductase (HMGCR)
Phenicin (Phoenicine), a microbial metabolite, is an irreversible HMG-CoA reductase (HMGCR) inhibitor. Phenicin can be isolated from cultures of Penicillium phoeniceum and Penicillium rubrum. Phenicin specifically inhibits the conversion of HMG-CoA to mevalonate catalyzed by HMGCR, effectively inhibiting cholesterol synthesis .

HY-100313

YM-53601 free base	Alkaloids Carbazole Alkaloids	Farnesyl Transferase HCV
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent ^[2]. YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-N0352R

Tuberostemonine (Standard)	Structural Classification Alkaloids other families Pyrrole Alkaloids Plants Source Classification	Reference Standards Parasite
Tuberostemonine (Standard) is the analytical standard of Tuberostemonine. This product is intended for research and analytical applications. Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine has a level of activity as a feeding deterrent ^[2].

HY-N10076

Ganomycin I	Microorganisms Phenols Polyphenols Source Classification	HMG-CoA Reductase (HMGCR) Glycosidase HIV Protease
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects ^[2].

HY-W327449R

Feruloylputrescine (Standard)	Structural Classification Monophenols Gramineae Phenols Oryza sativa L. Plants Source Classification	Cytochrome P450 Reference Standards
Feruloylputrescine is an oral active phenolamide found in citrus plants and formed through the decarboxylation of L-Arginine. Feruloylputrescine inhibits monooxygenase (cntA) and reductase (cntB) and trimethylamine production. Feruloylputrescine can be used for cardiovascular diseases research .

HY-N9898

Sinocrassoside C1	Structural Classification Sinocrassula indica (Decne.) Berger Flavonols Flavonoids Crassulaceae Plants Source Classification	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

HY-F0002AR

NADP disodium salt (Standard) Disodium NADP (Standard)	Structural Classification other families Microorganisms Animals Ketones, Aldehydes, Acids Plants Source Classification	Endogenous Metabolite Reference Standards
NADP (disodium salt) (Standard) is the analytical standard of NADP (disodium salt). This product is intended for research and analytical applications. NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

HY-N12472

Floramanoside C	Malvaceae Flavonols Flavonoids Abelmoschus manihot (Linn.) Medicus Plants Source Classification	Aldose Reductase
Floramanoside C shows 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities .

HY-N7962

Cornoside	Phyla nodiflora (L.) E. L. Greene Quinones Classification of Application Fields Verbenaceae Benzene Quinones Plants Disease Research Fields Inflammation/Immunology Source Classification	Aldose Reductase
Cornoside is a phenolic glycoside and has inhibitory effect on rat lens aldose reductase (AR) with an IC₅₀ of 150 μM .

HY-N2494

Hydroxyevodiamine	Alkaloids other families Classification of Application Fields Plants Disease Research Fields Inflammation/Immunology Source Classification Indole Alkaloids	Aldose Reductase
Hydroxyevodiamine inhibits aldose reductase with an IC₅₀ value of 24.1 μM .

HY-N9335

Myrciacetin	Flavonoids Rhododendron dauricum Linn. Flavonones Phenols Polyphenols Plants Ericaceae Source Classification	Aldose Reductase
Myrciacetin is a flavonoid from Rhododendron dauricum. Myrciacetin is against rat lens aldose reductase with an IC₅₀ of 13 μM .

HY-N9903

Tetrahydrodehydrodiconiferyl alcohol TDDC	Epimedium grandiflorum C. Morren Plants Berberidaceae Source Classification	Others
Tetrahydrodehydrodiconiferyl alcohol (TDDC) is a reduction product of dihydrodehydrodiconiferyl alcohol catalyzed by phenylcoumaran benzylic ether reductase. Tetrahydrodehydrodiconiferyl alcohol can be isolated from a hydrogenolysis product of protolignin .

HY-113342R

7-Ketocholesterol (Standard)	Structural Classification Triterpenes Terpenoids Endogenous metabolite Source Classification	Endogenous Metabolite p38 MAPK Reference Standards
7-Ketocholesterol (Standard) is the analytical standard of 7-Ketocholesterol. This product is intended for research and analytical applications. 7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-113377A

L-Glyceric acid sodium	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2 ^[2].

HY-N0033R

Poliumoside (Standard)	Structural Classification Simple Phenylpropanols Verbenaceae Scrophulariaceae Callicarpa formosana Rolfe Phenols Polyphenols Phenylpropanoids Plants Source Classification Brandisia hancei Hook. f.	Reference Standards Aldose Reductase
Poliumoside (Standard) is the analytical standard of Poliumoside. This product is intended for research and analytical applications. Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity ^[2] .

HY-183972

Desaspidin	Structural Classification Dryopteridaceae Dryopteris championii (Benth.) C. Chr. Other Phenylpropanoids Phenylpropanoids Plants Source Classification	Oxidative Phosphorylation
Desaspidin is an oxidative phosphorylation inhibitor and photophosphorylation inhibitor. Desaspidin uncouples mitochondrial oxidative phosphorylation, multiple chloroplast photophosphorylation pathways, and ATP synthesis linked to non-cyclic NADP reduction. Desaspidin can be used for the research of anthelmintic agent ^[2] .

HY-165368

Atromentin	Structural Classification Microorganisms Phenols Polyphenols Source Classification	Bacterial
Atromentin, a phthalide derivative that can be isolated from the wood fungus Hypoxylon fendleri BCC32408, is a selective enoyl-ACP reductase FabK inhibitor with an IC₅₀ of 0.24 μM. Atromentin exhibits selectivity over FabI. Atromentin can be used for antimicrobial research ^[2].

HY-N17587

3,24-Diacetate barbinervic acid	Structural Classification Coussarea brevicaulis K.Krause Terpenoids Rubiaceae Plants Pentacyclic Triterpenoids Source Classification	Others
3,24-Diacetate barbinervic acid is a triterpenoid derivative found in the stems of Coussarea brevicaulis .

HY-N10706

3-Keto sphinganine (d18:0)	Structural Classification Natural Products Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
3-Keto sphinganine (d18:0) serves as the substrate for 3-keto-dihydrosphingosine reductase in the de novo sphingolipid synthesis pathway, and is a key intermediate in the de novo synthesis of sphingoid long-chain bases. 3-Keto sphinganine (d18:0) can be used in studies related to thrombocytopenia, anemia .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent ^[2] .

HY-14664AS

Fluvastatin-d6 sodium
Fluvastatin-d₆ (sodium) is deuterium labeled Fluvastatin sodium. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.

HY-W003972S1

2,6-Dimethoxyphenol-d6
2,6-Dimethoxyphenol-d₆ (Syringol-d₆) is deuterated labeled 2,6-Dimethoxyphenol (HY-W003972). 2,6-Dimethoxyphenol is a phenolic compound that scavenges free radicals and exhibits antioxidant activity. 2,6-Dimethoxyphenol is the substrate for determining laccase activity ^[2].

HY-14519S1

Methotrexate-d3 diammonium

Methotrexate-d₃ diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) ^[2] .

HY-14664DS

(3S,5R)-Fluvastatin-d6
(3S,5R)-Fluvastatin-d₆ is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive?HMG-CoA reductase?inhibitor with an IC₅₀?of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

Targets Recommended: Quinone Reductase 5 alpha Reductase Carbonyl Reductase Glutathione Reductase (GR) Aldose Reductase TrxR Dihydrofolate reductase (DHFR) HMG-CoA Reductase (HMGCR) GSNOR VKOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19980G

Eprenetapopt APR-246; PRIMA-1Met	MDM-2/p53 Apoptosis Autophagy Ferroptosis	Cancer
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance ^[2] .

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