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Cat. No.: HY-161472

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Aldose reductase-IN-7

Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase. Aldose reductase-IN-7 exhibits potent enzyme inhibitory activity (K_i = 0.186 ± 0.020 μM), showing superiority to Epalrestat (HY-66009), which is currently in clinical use. Aldose reductase-IN-7 is less cytotoxic and possesses potent anticancer activity.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₀N₄O₇
Molecular Weight:440.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Aldose reductase-IN-7 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Aldose reductase-IN-7 (24 h) shows low cytotoxicity in L929 cells (IC₅₀ = 569.58 ± 0.80 μM). Significant anticancer activity can be observed in MCF-7 cells (IC₅₀ = 110.87 ± 0.42 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

L929 cells and MCF-7 cells
Concentration:
Incubation Time:

24h
Result:

Ideally, killed cancer cells without harming healthy cells (S_I value of 5.13). Specifically inhibited the proliferation of cancer cells compared to non-cancerous cells.

Chemical Information

Molecular Weight 440.41
Formula C₂₁H₂₀N₄O₇
SMILES

O=C(OCC)CN(C1=CC=C([N+]([O-])=O)C=C1C23OC(CC4=CC=C(OC)C=C4)=NN3)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Güleç Ö, et al. Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies. Bioorg Chem. 2024 Apr;145:107221. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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