Dantrolene (sodium hemiheptahydrate) (Standard)
Dantrolene (sodium hemiheptahydrate) (Standard) is the analytical standard of Dantrolene (sodium hemiheptahydrate). This product is intended for research and analytical applications. Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene sodium hemiheptahydrate is a direct-acting skeletal muscle relaxant. Dantrolene sodium hemiheptahydrate can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 24868-20-0
- Formula: C14H16N4NaO8.5
- Molecular Weight:399.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-12542A
Dantrolene sodium hemiheptahydrate -
HY-B0284
Nifedipine -
HY-B0284R
Nifedipine (Standard) -
HY-B1077
Penfluridol -
HY-100831
YM-58483 -
HY-B0233
Isradipine -
HY-B0309
Felodipine -
HY-B0424
Nitrendipine -
HY-12515A
Nicardipine hydrochloride -
HY-17402
Nisoldipine -
HY-B0347
Lacidipine -
HY-17401
Ranolazine dihydrochloride
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 24868-20-0
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Molecular Weight 399.31
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Formula C14H16N4NaO8.5
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SMILES
O=C1N([Na])C(CN1/N=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O.[3.5H2O]
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Synonyms
Dantrolene sodium hydrate (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Murat Sentürk, et al. Dantrolene inhibits human erythrocyte glutathione reductase. Biol Pharm Bull. 2008 Nov;31(11):2036-9. [Content Brief]
[2]. Christopher B Sylvester, et al. Dantrolene inhibits lysophosphatidylcholine-induced valve interstitial cell calcific nodule formation via blockade of the ryanodine receptor. Front Cardiovasc Med. 2023 Mar 30:10:1112965. [Content Brief]
[3]. Xi Chen, et al. Dantrolene is neuroprotective in Huntington's disease transgenic mouse model. Mol Neurodegener. 2011 Nov 25;6:81. [Content Brief]
[4]. Benjamin Liou, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 Dec 1;25(23):5126-5141. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dantrolene (sodium hemiheptahydrate) (Standard) Related Classifications
HY-12542AR Related Classifications
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Keywords
- Dantrolene (sodium hemiheptahydrate) (Standard)
- 24868-20-0
- Dantrolene sodium hydrate (Standard)
- Reference Standards
- Calcium Channel
- Autophagy
- orally
- non-competitive
- glutathione reductase
- ryanodine receptor
- RyR
- Ca2+
- muscle spasticity
- malignant hyperthermia
- Huntington's disease
- neuroleptic malignant syndrome
- Inhibitor
- inhibitor
- inhibit