Trimethoprim sulfate
Based on 13 publication(s) in Google Scholar
Trimethoprim sulfate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim sulfate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim sulfate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim sulfate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc.
For research use only. We do not sell to patients.
- CAS No.: 56585-33-2
- Formula: C14H20N4O7S
- Molecular Weight:388.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Trimethoprim sulfate
More- Autophagy. 2023 Oct;19(10):2702-2718. [Abstract]
- Water Res. 2023 Jul 15:240:120110. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Food Chem X. 2026 Feb 8:34:103646. [Abstract]
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Microorganisms. 2025 Apr 18;13(4):938. [Abstract]
- J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- bioRxiv. 2026 Apr 29.
- Res Sq. 2026 Mar 9.
- bioRxiv. 2025 January 15.
- bioRxiv. 2024 May 10.
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Bio/Physico-chemical Assay
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Biological Activity
Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF)[1].
Trimethoprim (3 μg/mL; 1 h) induces protein aggregation and main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim sulfate presence leads to protein misfolding[1].
Trimethoprim (1.5-3 μg/mL; 1 h) causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps in E. coli cells exposed to folate and heat stress[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Trimethoprim can be connected with the thiomaltose (TM-TMP) and shows stability with a half-life of about 1 hour in complete serum, and has an MIC value around 1 μM against E. coli[2].
Trimethoprim (10 mg/mL; 0.5 mL; inject with Trimethoprim-Zn combined suspension) decreases the virus titer and increases the survival rate of chicken embryo[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C3H/HeOuJ mice (transurethrally infected with a 50 μL suspension containing 1-2×107 CFU of E. coli under 3% isoflurane)[2]
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Dosage:10 mg/kg
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Administration:i.v.; once every 12 h; for 3 d
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Result:Showed antibacterial activity against H. influenzae, S. pneumoniae, E. coli and N. meningitidis with CD50s of 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively in infected mice.
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Animal Model:Fertilized eggs (injected H3N2 virus into amniotic and allantoic space at day 8)[4]
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Dosage:10 mg/mL; 0.5 mL
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Administration:The Trimethoprim-Zn combined suspension was injected into the air sac; single dosage
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Result:Decreased the virus titer and increased the survival rate of chicken embryo.
The survival rate peaked at ratio about 0.18 (Zn/Trimethoprim).
Chemical Information
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CAS No. 56585-33-2
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Molecular Weight 388.40
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Formula C14H20N4O7S
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SMILES
NC1=NC(N)=NC=C1CC2=CC(OC)=C(OC)C(OC)=C2.O=S(O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (13)
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Journal Impact Factor
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Most Recent
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Autophagy
2023 Oct;19(10):2702-2718. PMID: 37312409 -
Water Res
Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]2023 Jul 15:240:120110. PMID: 37247434 -
J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Food Chem X
Machine learning prioritization of antibiotic residues in aquatic foods reveals exposure-driven genotoxic risk mediated by BCL2. [Abstract]2026 Feb 8:34:103646. PMID: 41756597 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Microorganisms
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023. [Abstract]2025 Apr 18;13(4):938. PMID: 40284774 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
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Trimethoprim sulfate purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 January 15.
Inhibitory effect of Trimethoprim on Babesia.
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Purity & Documentation
References
[1]. Laskowska, E., et al., Trimethoprim sulfate induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47(4): p. 286-9. [Content Brief]
[2]. Xiaojian Wang, et al. A Trimethoprim sulfate Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29(5):1729-1735. [Content Brief]
[3]. Brogden, R.N., et al., Trimethoprim sulfate: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs, 1982. 23(6): p. 405-30. [Content Brief]
[4]. El Habbal MH. Combination therapy of zinc and trimethoprim inhibits infection of influenza A virus in chick embryo. Virol J. 2021 Jun 3;18(1):113. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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