1. Cell Cycle/DNA Damage
    Anti-infection
  2. Antifolate
    Bacterial
  3. Trimethoprim lactate

Trimethoprim lactate 

Cat. No.: HY-B0510C
Handling Instructions

Trimethoprim lactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactic has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment.

For research use only. We do not sell to patients.

Trimethoprim lactate Chemical Structure

Trimethoprim lactate Chemical Structure

CAS No. : 23256-42-0

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Description

Trimethoprim lactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactic has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].

IC50 & Target

Dihydrofolate reductase[1]
Bacteria[1]

In Vitro

Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF)[1].
Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In intraperitoneal infections in mice, the CD50 values for Trimethoprim alone against H. influenzae, S. pneumoniae, E. coli and N. meningitidis, is 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

380.40

Formula

C₁₇H₂₄N₄O₆

CAS No.

23256-42-0

SMILES

CC(O)C(O)=O.NC1=NC=C(CC2=CC(OC)=C(OC)C(OC)=C2)C(N)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TrimethoprimAntifolateBacterialAntimicrobialfolatemetabolismdihydrofolatereductasetetrahydrofolateHspsproteinaggregationInhibitorinhibitorinhibit

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Product Name:
Trimethoprim lactate
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HY-B0510C
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