Levoleucovorin Calcium
Based on 3 publication(s) in Google Scholar
Levoleucovorin Calcium (Calcium levofolinate) is the active form of calcium Folinic acid (HY-13664) and has anti-tumor effects. Levoleucovorin Calcium is also a potentiator of the anti-cancer toxicity of 5-Fluorouracil (HY-90006).
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 80433-71-2
- Formula: C20H21CaN7O7
- Molecular Weight:511.50
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Natural Product Library
HY-L021
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FDA-Approved Drug Library
HY-L022
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Drug Repurposing Compound Library
HY-L035
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Anti-COVID-19 Compound Library
HY-L052
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NMPA-Approved Drug Library
HY-L053
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FDA Approved & Pharmacopeial Drug Library
HY-L066
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Cancer Metabolism Compound Library
HY-L083
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Pediatric Drug Library
HY-L104
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Anti-Cancer Natural Product Library
HY-L107
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FDA-Approved Anticancer Drug Library
HY-L122
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Off-patent Drug Library
HY-L141
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Natural Product Library Plus
HY-L021P
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Drug Repurposing Compound Library Plus
HY-L035P
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FDA-Approved Drug Library Plus
HY-L022P
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FDA-Approved Drug Library Mini
HY-L022M
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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High-Throughput Natural Product Library
HY-L206
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Anti-Cancer Approved Drug Library
HY-L213
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Mass Spectrometry Natural Product Library
HY-L262
Publications Citing Use of MedChemExpress (MCE) Levoleucovorin Calcium
More
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Crj:CD(SD)BR rats (5 weeks)[2]
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Dosage:6, 20 or 60 mg/kg/day
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Administration:i.v.; for 4 weeks (combined with 10 mg/kg/day 5-Fluorouracil)
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Result:Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs.
Induced the potentiation in the toxicity of 5-Fluorouracil appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 80433-71-2
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Appearance Solid
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Molecular Weight 511.50
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Formula C20H21CaN7O7
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Color White to yellow
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SMILES
O=C1C2=C(NC[C@H](CNC3=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C3)N2C=O)NC(N)=N1.[Ca+2]
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Synonyms
Calcium levofolinate; CL307782
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. [Abstract]2023 Sep 25;14(1):5534. PMID: 37749092 -
Mol Cancer Ther
Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer. [Abstract]2025 Dec 4. PMID: 41340484 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471
Solvent & Solubility
H2O : 7.69 mg/mL (15.03 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.9550 mL | 9.7752 mL | 19.5503 mL | 48.8759 mL |
| 5 mM | 0.3910 mL | 1.9550 mL | 3.9101 mL | 9.7752 mL | |
| 10 mM | 0.1955 mL | 0.9775 mL | 1.9550 mL | 4.8876 mL | |
| 15 mM | 0.1303 mL | 0.6517 mL | 1.3034 mL | 3.2584 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Levoleucovorin Calcium Related Classifications
HY-13667 Related Classifications
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