2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Levoleucovorin Calcium

Levoleucovorin Calcium  (Synonyms: Calcium levofolinate; CL307782)

Cat. No.: HY-13667 Purity: 99.52%
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Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer.

For research use only. We do not sell to patients.

Levoleucovorin Calcium Chemical Structure

Levoleucovorin Calcium Chemical Structure

CAS No. : 80433-71-2

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Based on 1 publication(s) in Google Scholar

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  • References

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Description

Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer[1][2].

In Vivo

Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of 5-Fluorouracil[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Crj:CD(SD)BR rats (5 weeks)[2]
Dosage: 6, 20 or 60 mg/kg/day
Administration: i.v.; for 4 weeks (combined with 10 mg/kg/day 5-Fluorouracil)
Result: Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs.
Induced the potentiation in the toxicity of 5-Fluorouracil appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil.
Clinical Trial
Molecular Weight

511.50

Appearance

Solid

Formula

C20H21CaN7O7
CAS No.
SMILES

O=C1C2=C(NC[[email protected]](CNC3=CC=C(C(N[[email protected]](C([O-])=O)CCC([O-])=O)=O)C=C3)N2C=O)NC(N)=N1.[Ca+2]
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (19.55 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9550 mL 9.7752 mL 19.5503 mL
5 mM 0.3910 mL 1.9550 mL 3.9101 mL
10 mM 0.1955 mL 0.9775 mL 1.9550 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Levoleucovorin80433-71-2Calcium levofolinate CL307782CL307782CL 307782CL-307782Antifolateanticancerantineoplastic5-FluorouracilInhibitorinhibitorinhibit

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