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Cat. No.: HY-184336

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Antimycobacterial agent-17

Antimycobacterial agent-17 is an anti-tuberculosis and Antibacterial agent. Antimycobacterial agent-17 inhibits the growth of both agent-susceptible and agent-resistant Mycobacterium tuberculosis strains. Antimycobacterial agent-17 can be used in the research of tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 3125811-49-3
Formula: C₂₁H₂₁BrN₄O
Molecular Weight:425.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimycobacterial agent-17 Chemical Structure

CAS No.: 3125811-49-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Antimycobacterial agent-17 (Compound 5m) (0.25-64 μg/mL) inhibits the growth of Mycobacterium tuberculosis mc²6230, with an MIC of 1 μg/mL^[1].
Antimycobacterial agent-17 inhibits the growth of isoniazid (HY-B0329)-resistant, rifampicin (HY-B0272)-resistant, and multidrug-resistant Mycobacterium tuberculosis strains with MIC values of 2 μg/mL, 0.5 μg/mL, and 1 μg/mL, respectively^[1].
Antimycobacterial agent-1 exhibits a CC₅₀ of 21.93 μg/mL in HepG2 cells and a CC₅₀ of 2.16 μg/mL in THP-1 cells, with selectivity indices of 21.93 and 2.16, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3125811-49-3
Molecular Weight 425.32
Formula C₂₁H₂₁BrN₄O
SMILES

CC(C)(C)C(C=C1)=CC=C1C(N/N=C/C(C=C2)=CC=C2N3C=C(Br)C=N3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kumar P, et al. Structure-activity relationship-driven lead optimization of pyrazole hydrazide-hydrazone analogues as potent antimycobacterial agents: in vitro and in silico studies. Bioorganic & medicinal chemistry letters. 2026 Jul;136:130601. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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