Antimycobacterial agent-17 

Antimycobacterial agent-17 is an anti-tuberculosis and Antibacterial agent. Antimycobacterial agent-17 inhibits the growth of both agent-susceptible and agent-resistant Mycobacterium tuberculosis strains. Antimycobacterial agent-17 can be used in the research of tuberculosis^[1].

Antimycobacterial agent-17 (Compound 5m) (0.25-64 μg/mL) inhibits the growth of Mycobacterium tuberculosis mc²6230, with an MIC of 1 μg/mL^[1].
Antimycobacterial agent-17 inhibits the growth of isoniazid (HY-B0329)-resistant, rifampicin (HY-B0272)-resistant, and multidrug-resistant Mycobacterium tuberculosis strains with MIC values of 2 μg/mL, 0.5 μg/mL, and 1 μg/mL, respectively^[1].
Antimycobacterial agent-1 exhibits a CC₅₀ of 21.93 μg/mL in HepG2 cells and a CC₅₀ of 2.16 μg/mL in THP-1 cells, with selectivity indices of 21.93 and 2.16, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

425.32

C₂₁H₂₁BrN₄O

3125811-49-3

CC(C)(C)C(C=C1)=CC=C1C(N/N=C/C(C=C2)=CC=C2N3C=C(Br)C=N3)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kumar P, et al. Structure-activity relationship-driven lead optimization of pyrazole hydrazide-hydrazone analogues as potent antimycobacterial agents: in vitro and in silico studies. Bioorganic & medicinal chemistry letters. 2026 Jul;136:130601.  [Content Brief]