country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-169818

Copy Link Print Information

Keto lovastatin

Name: Keto lovastatin
Brand: MedChemExpress
SKU: HY-169818
Price: 250.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Monacolin X)

Keto lovastatin (Monacolin X) is an impurity of Lovastatin (HY-N0504) and also a competitive inhibitor of HMG-CoA reductase. Keto lovastatin exerts its cholesterol-lowering effect by blocking the rate-limiting step of endogenous cholesterol synthesis. Keto lovastatin can be used in research on hypercholesterolemia and atherosclerosis, and can also serve as an impurity reference standard in the research on the production and quality control of Lovastatin.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 96497-73-3
화학식: C₂₄H₃₄O₆
분자량:418.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Keto lovastatin Chemical Structure

CAS No.: 96497-73-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Keto lovastatin (Monacolin X) (up to 1000 ng/mL; 2 h) inhibits cholesterol synthesis in human umbilical vein endothelial cells (HUVEC), human enterocytes, normal human skin fibroblasts, and familial homozygous hypercholesterolemia LDL receptor-deficient human skin fibroblasts, with no significant inhibitory effect on protein synthesis or fatty acid synthesis^[2].

Keto lovastatin (up to 1000 ng/mL; 2 h) inhibits cholesterol synthesis in human hepatoma cells HEPG2, and its lactone and ring-opened acid forms exhibit comparable inhibitory activity, with no significant inhibitory effect on protein synthesis or fatty acid synthesis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS No. 96497-73-3
분자량 418.52
화학식 C₂₄H₃₄O₆
SMILES

O=C1OC(CC(C1)O)CCC2C(C)C=CC3=CC(CC(C32)OC(C(C)C(C)=O)=O)C
Synonyms

Monacolin X
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Belwal C, et al. Isolation, Identification, and Characterization of an Unknown Impurity in Lovastatin EP. Scientia pharmaceutica. 2014;82(1):43-52.

[2]. Sviridov DD, et al. Comparison of the effect of six compactin-related compounds on cholesterol synthesis in five human cell types. Lipids. 1990 Nov;25(11):685-90.

[3]. McKenney JM, et al. Pharmacologic characteristics of statins. Clinical cardiology. 2003 Apr;26(4 Suppl 3):III32-8.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기