96497-73-3
Chemical Structure
Keto lovastatin
Synonym(s): Monacolin X
- CAS No.: 96497-73-3
- Formula:C24H34O6
- Molecular Weight:418.52
InChIKey: NXZRZXCVBJAQDF-UHFFFAOYSA-N
SMILES: O=C1OC(CC(C1)O)CCC2C(C)C=CC3=CC(CC(C32)OC(C(C)C(C)=O)=O)C
Biological Activity: Keto lovastatin (Monacolin X) is an impurity of Lovastatin (HY-N0504) and also a competitive inhibitor of HMG-CoA reductase. Keto lovastatin exerts its cholesterol-lowering effect by blocking the rate-limiting step of endogenous cholesterol synthesis. Keto lovastatin can be used in research on hypercholesterolemia and atherosclerosis, and can also serve as an impurity reference standard in the research on the production and quality control of Lovastatin[1][2][3].
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Keto lovastatin | Keto lovastatin (Monacolin X) is an impurity of Lovastatin (HY-N0504) and also a competitive inhibitor of HMG-CoA reductase. Keto lovastatin exerts its cholesterol-lowering effect by blocking the rate-limiting step of endogenous cholesterol synthesis. Keto lovastatin can be used in research on hypercholesterolemia and atherosclerosis, and can also serve as an impurity reference standard in the research on the production and quality control of Lovastatin. | |||||||||||||||||||||
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References
- [1]. Belwal C, et al. Isolation, Identification, and Characterization of an Unknown Impurity in Lovastatin EP. Scientia pharmaceutica. 2014;82(1):43-52.
- [2]. Sviridov DD, et al. Comparison of the effect of six compactin-related compounds on cholesterol synthesis in five human cell types. Lipids. 1990 Nov;25(11):685-90.
- [3]. McKenney JM, et al. Pharmacologic characteristics of statins. Clinical cardiology. 2003 Apr;26(4 Suppl 3):III32-8.
