2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. TrxR Reactive Oxygen Species (ROS)
  4. FEACYP

FEACYP is a thioredoxin reductase (TrxR) inhibitor. FEACYP inhibits thioredoxin reductase activity, induces ROS by increasing basal cellular hydrogen peroxide production, suppresses tumor growth, exerts cytotoxicity against human cancer cells, and exhibits antiproliferative activity in human pancreatic cancer 3D spheroids. FEACYP can be used in the research of ovarian cancer, colon cancer, pancreatic cancer, and lung cancer.

For research use only. We do not sell to patients.

FEACYP

FEACYP Chemical Structure

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FEACYP Related Antibodies

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Description

FEACYP is a thioredoxin reductase (TrxR) inhibitor. FEACYP inhibits thioredoxin reductase activity, induces ROS by increasing basal cellular hydrogen peroxide production, suppresses tumor growth, exerts cytotoxicity against human cancer cells, and exhibits antiproliferative activity in human pancreatic cancer 3D spheroids. FEACYP can be used in the research of ovarian cancer, colon cancer, pancreatic cancer, and lung cancer[1].

In Vitro

FEACYP (compound 2a) (72 h) potently inhibits the viability of 2008, HCT-15, PSN-1, and U1285 human cancer cells with IC50 values ranging from 2.6-4.3 μM, and is 6.2-fold more selective for cancer cells than noncancerous HEK293 cells[1].
FEACYP (72 h) inhibits Cisplatin (HY-17394)-resistant C13* human ovarian adenocarcinoma cells with an IC50 of 7.3 μM[1].
FEACYP (72 h) potently inhibits the viability of 3D PSN-1 human pancreatic cancer spheroids with an IC50 of 16.2 μM[1].
FEACYP (5 μM; 24 h) inhibits thioredoxin reductase activity in PSN-1 human pancreatic cancer cells by 52%, matching the inhibitory capacity of Auranofin (HY-B1123)[1].
FEACYP induces a time-dependent increase in reactive oxygen species production in PSN-1 human pancreatic cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FEACYP Related Antibodies
In Vivo

FEACYP (compound 2a) (8 mg/kg; daily) induces 88% tumor growth inhibition in syngeneic murine LLC carcinoma with limited body weight loss and no systemic toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, 24±3 g, Female C57BL/6 mice (LLC cells) [1]
Dosage: 8 mg/kg
Administration: I.p.; daily for 15 days
Result: Reduced the average tumor growth by 88% with less body weight loss pronounced (∼12%).
Molecular Weight

729.33

Formula

C27H37F3Fe2N4O5PS
SMILES

C[n](C1CCCCC1)[c+]2[Fe]3([P@]4(CN5C6)CN(C5)CN6C4)([])[Fe]2(C3=O)(C=O)[].[O-]S(=O)(C(F)(F)F)=O.c7cccc7.c8cccc8
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FEACYP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FEACYPTrxRReactive Oxygen Species (ROS)Thioredoxin Reductasethioredoxin reductasehuman pancreatic cancer 3D spheroidsovarian cancerpancreatic cancermurine LLC carcinoma modelsLewis lung carcinomacolon cancerlung cancerHEK293 cellshuman cancer cellsInhibitorinhibitorinhibit

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