5,10-Dideazafolic acid
5,10-Dideazafolic acid is a 5,10-dideaza-5,6,7,8-tetrahydrofola analogue, which exhibits some inhibitory activity against glycine amide ribonucleotide formyltransferase (GARFT) (Ki=13 μM).
For research use only. We do not sell to patients.
- CAS No.: 85597-18-8
- Formula: C21H21N5O6
- Molecular Weight:439.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
60 nM
Compound: DDATHF
|
Inhibitory activity against the growth of CEM human leukoblast cells; value ranges from 20-60
Inhibitory activity against the growth of CEM human leukoblast cells; value ranges from 20-60
|
[PMID: 2918520] |
| CCRF-CEM | IC50 |
16.2 nM
Compound: DDATHF
|
Tested in vitro for inhibitory concentration against CCRF-CEM human Leukemic lymphoblast by using GAR FTase as primary target
Tested in vitro for inhibitory concentration against CCRF-CEM human Leukemic lymphoblast by using GAR FTase as primary target
|
[PMID: 8035423] |
| L1210 | IC50 |
60 nM
Compound: DDATHF
|
Inhibitory activity against the growth of murine L1210 leukemia cells; value ranges from 20-60
Inhibitory activity against the growth of murine L1210 leukemia cells; value ranges from 20-60
|
[PMID: 2918520] |
| L1210 | IC50 |
>0.0001 M
Compound: 3
|
Inhibitory concentration against the growth of L1210 murine leukemia cells in tissue culture.
Inhibitory concentration against the growth of L1210 murine leukemia cells in tissue culture.
|
[PMID: 4009615] |
| L1210 | IC50 |
>0.1 mM
Compound: 3
|
Inhibitory concentration against the growth of L1210 murine leukemia cells in tissue culture.
Inhibitory concentration against the growth of L1210 murine leukemia cells in tissue culture.
|
[PMID: 4009615] |
Chemical Information
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CAS No. 85597-18-8
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Molecular Weight 439.42
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Formula C21H21N5O6
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SMILES
O=C(CC[C@H](NC(C1=CC=C(C=C1)CCC2=CN=C(NC(N)=NC3=O)C3=C2)=O)C(O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)