DHFR-IN-24
DHFR-IN-24, a benzothiazole derivative, is a dihydrofolate reductase (DHFR) inhibitor. DHFR-IN-24 has intrinsic antibacterial activity against both Gram-positive and Gram-negative strains. DHFR-IN-24 synergistically combines DHFR inhibition with photodynamic therapy (PDT) for enhanced antibacterial activity against multidrug-resistant pathogens.
For research use only. We do not sell to patients.
- CAS No.: 1088704-78-2
- Formula: C22H21IN2S2
- Molecular Weight:504.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DHFR-IN-24 (compound 12) inhibits MRSA ATCC 33591, S. aureus ATCC 25923, S. epidermidis CICC 10436, A. baumannii Bio 34235, A. baumanniiBio 53272, E. coli ATCC 25922, and K. pneumoniae CICC 21611, with MIC values of 0.5 μg/mL, 0.5 μg/mL, 2 μg/mL, 16 μg/mL, 16 μg/mL, 4 μg/mL, and 8 μg/mL, respectively[1].
Photodynamic activation of DHFR-IN-24 enhanced its antimicrobial efficacy by up to 64-fold through efficient generation of reactive oxygen species (ROS) in MRSA[1].
DHFR-IN-24 possesses inherent antibacterial activity and exhibits significantly enhanced antibacterial activity upon photodynamic activation[1].
DHFR-IN-24 exhibits significant time- and concentration-dependent antibacterial effects against both Gram-positive and Gram-negative bacteria[1].
DHFR-IN-24 demonstrates potent light-enhanced antibiofilm activity against MRSA and A. baumannii[1].
DHFR-IN-24 does not show significant cytotoxicity against human embryonic kidney cells (HEK293T) and cervical cancer cells (HeLa)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c (Male, 6-8 weeks, 180-220 g) were subsequently inoculated with 10μL of MRSA suspension[1].
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Dosage:0.5 mg/mLwith lightexposure
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Administration:Topical; 14 days
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Result:At the experimental end point (day 14), the photodynamic therapy group achieved near-complete wound healing with complete absence of inflammatory signs.
Chemical Information
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CAS No. 1088704-78-2
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Molecular Weight 504.45
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Formula C22H21IN2S2
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SMILES
CN(C1=CC=C(C=C1)C2=CC=C(S2)/C=C/C3=[N+](C4=CC=CC=C4S3)C)C.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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