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  2. Msr-blue

Msr-blue 

Cat. No.: HY-D1256
Handling Instructions

Msr-blue is a first turn-on fluorescent probe for methionine sulfoxide reductase with a more than 100-fold fluorescence increment. Msr-blue is used for monitoring the enzyme activity in live cells (λex=340 nm, λem=440 nm).

For research use only. We do not sell to patients.

Msr-blue Chemical Structure

Msr-blue Chemical Structure

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Description

Msr-blue is a first turn-on fluorescent probe for methionine sulfoxide reductase with a more than 100-fold fluorescence increment. Msr-blue is used for monitoring the enzyme activity in live cells (λex=340 nm, λem=440 nm)[1].

In Vitro

Msr-blue is emited blue fluorescence after activation by methionine sulfoxide reductase A (Msr A). Msr-blue responded to Msr A in both a time- and dose-dependent manner, and more than a 100-fold increase in the emission is observed. Msr-blue is converted to its corresponding sulfide (15′) under catalysis by either the purified Msr A or a cell lysate[1].
The 6-OHDA-treated PC12 cells as a cellular model of Parkinson's disease (PD) is employed and applied Msr-blue to probe the function of Msrs in the cells. With the aid of Msr-blue, a decline of the Msr activity in a PD model was disclosed for the first time[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

222.26

Formula

C₁₁H₁₀O₃S

SMILES

CC(C1=CC=C(C=C1O2)S(C)=O)=CC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Msr-blueOthersfluorescentmethioninesulfoxidereductaselivecellssulfideMsrAInhibitorinhibitorinhibit

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Msr-blue
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HY-D1256
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