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Cat. No.: HY-184209

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Antifungal agent-163

Antifungal agent-163 is an antifungal agent. Antifungal agent-163 inhibits the activity of coenzyme Q-cytochrome C reductase (CoQ-Ccr), thereby disrupting electron transport in the mitochondrial respiratory chain. Antifungal agent-163 induces intracellular ROS accumulation, causes cell membrane damage, and impairs mitochondrial function in *Sublineola* cells. Antifungal agent-163 exhibits control effects against fungal plant diseases. Antifungal agent-163 can be used in the research of sorghum anthracnose.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₄N₂O₄
Molecular Weight:392.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

Antifungal agent-163 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Antifungal agent-163 (Compound A₂₃) potently inhibits the mycelial growth of Colletotrichum sublineola (EC₅₀ = 0.680 μg/mL) and Colletotrichum fructicola (EC₅₀ = 2.11 μg/mL) in vitro, and exhibits strong activity against C. sublineola at a concentration of 25.0 μg/mL^[1].
Antifungal agent-163 (0-50.0 μg/mL; 48 h) potently inhibits the activity of cytochrome bc₁ complex in hyphae of Colletotrichum sublineola, with an IC₅₀ of 16.6 μg/mL and an inhibition rate of up to 91.1% at the concentration of 50.0 μg/mL^[1].
Antifungal agent-163 (12.5-25.0 μg/mL; 48 h) induces reactive oxygen species accumulation and cell membrane damage in hyphae of Colletotrichum sublineola^[1].
Antifungal agent-163 (12.5-25.0 μg/mL) causes severe morphological and ultrastructural damage to hyphae of Colletotrichum sublineola, including surface deformation, mitochondrial damage and disruption of cellular structures^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 392.45
Formula C₂₃H₂₄N₂O₄
SMILES

CC(/C=C/C1=NC2=CC=CC=C2C=C1)=N\OCC3=CC(OC)=C(OC)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang J, et al. Novel Insights into Quinoline-Based Oxime Ether Derivatives with E/Z Isomerization Possessing Antifungal Activity and Their Mechanism of Action. J Agric Food Chem. 2026;74(22):16881-16896. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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