Feruloyl-CoA  (Synonyms: Feruloyl-coenzyme A)

Feruloyl-CoA (Feruloyl-coenzyme A) is a cinnamoyl-CoA ester substrate involved in the biosynthesis of lignin and coumarin in plants. Feruloyl-CoA acts as a substrate for cinnamoyl-CoA reductase 1-dependent reduction reaction with NADPH to produce cinnamaldehyde. Feruloyl-CoA is a precursor that generates Scopoletin (HY-N0342) via spontaneous trans/cis isomerization and lactonization of its side chain^[1][2].

Feruloyl-CoA (0.5-5 µM) is efficiently catalyzed and reduced by purified recombinant Arabidopsis enzymes in an NADPH-dependent manner, with a K_m value of 0.42 µM, making it one of the most preferred natural substrates for this enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

943.70

C₃₁H₄₄N₇O₁₉P₃S

30802-02-9

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(/C=C/C4=CC(OC)=C(C=C4)O)=O)=O)=O)(O)=O)(O)=O)O3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Baltas M, et al. Kinetic and inhibition studies of cinnamoyl-CoA reductase 1 from Arabidopsis thaliana. Plant Physiol Biochem. 2005;43(8):746-753.  [Content Brief]

  [2]. Kai K, et al. Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana. Plant J. 2008;55(6):989-999.