Antibacterial agent 349 

Antibacterial agent 349 is an antibacterial agent. Antibacterial agent 349 impairs reactive oxygen species clearance, disrupts citrate cycle homeostasis and induces metabolic stress. Antibacterial agent 349 compromises bacterial membrane integrity, increases permeability, and causes intracellular component leakage. Antibacterial agent 349 can be used for the research of bacterial leaf streak^[1].

Antibacterial agent 349 (Compound M25) (50-100 mg/L) potently inhibits Xanthomonas oryzae pv oryzicola (Xoc) growth in vitro with an EC₅₀ of 25.3 mg/L^[1].
Antibacterial agent 349 (50-100 mg/L) inhibits Xanthomonas oryzae pv oryzae (Xoo) growth in vitro with an EC₅₀ of 83.6 mg/L^[1].
Antibacterial agent 349 (50-100 mg/L) inhibits Xanthomonas axonopodis pv citri (Xac) growth in vitro with an EC₅₀ of 86.6 mg/L^[1].
Antibacterial agent 349 (50-200 mg/L; 30-300 min) increases membrane permeability of Xanthomonas oryzae pv oryzicola (Xoc) in a concentration- and time-dependent manner, compromising cell membrane integrity^[1].
Antibacterial agent 349 (50-200 mg/L) induces concentration-dependent morphological damage to Xanthomonas oryzae pv oryzicola (Xoc) cell membranes, with significant shrinkage and drying observed at 100 mg/L and 200 mg/L^[1].
Antibacterial agent 349 binds to the Xanthomonas oryzae pv oryzicola (Xoc) AVRRXO1-ORF1:-ORF2 protein via multiple specific interactions, suggesting a potential protein target for its antibacterial activity^[1].
Antibacterial agent 349 (25-200 mg/L; 12 h) differentially regulates antioxidant enzyme activities in Xanthomonas oryzae pv oryzicola (Xoc), inhibiting CAT and SOD while upregulating GR in a concentration-dependent manner^[1].
Antibacterial agent 349 (50-200 mg/L) induces substantial proteomic reprogramming in Xanthomonas oryzae pv oryzicola (Xoc), altering 130 proteins to disrupt bacterial metabolic homeostasis^[1].
Antibacterial agent 349 (25-200 mg/L) concentration-dependently activates citrate synthase and isocitrate dehydrogenase in Xanthomonas oryzae pv oryzicola (Xoc), disrupting normal TCA cycle feedback regulation and metabolic homeostasis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

629.46

C₂₈H₂₆BrN₂O₆PS

O=S(OC(C=C1)=CC=C1N2CCN(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)CC2)(C5=CC=C(Br)C=C5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bai S, et al. Investigation of Antibacterial Activity and Mechanism of Action: Design and Synthesis of Phosphonate Derivatives Containing Sulfonate Ester Groups. J Agric Food Chem. 2026;74(22):17474-17485.