Antibacterial agent 349

Antibacterial agent 349 (Compound M25) (50-100 mg/L) potently inhibits Xanthomonas oryzae pv oryzicola (Xoc) growth in vitro with an EC₅₀ of 25.3 mg/L^[1].
Antibacterial agent 349 (50-100 mg/L) inhibits Xanthomonas oryzae pv oryzae (Xoo) growth in vitro with an EC₅₀ of 83.6 mg/L^[1].
Antibacterial agent 349 (50-100 mg/L) inhibits Xanthomonas axonopodis pv citri (Xac) growth in vitro with an EC₅₀ of 86.6 mg/L^[1].
Antibacterial agent 349 (50-200 mg/L; 30-300 min) increases membrane permeability of Xanthomonas oryzae pv oryzicola (Xoc) in a concentration- and time-dependent manner, compromising cell membrane integrity^[1].
Antibacterial agent 349 (50-200 mg/L) induces concentration-dependent morphological damage to Xanthomonas oryzae pv oryzicola (Xoc) cell membranes, with significant shrinkage and drying observed at 100 mg/L and 200 mg/L^[1].
Antibacterial agent 349 binds to the Xanthomonas oryzae pv oryzicola (Xoc) AVRRXO1-ORF1:-ORF2 protein via multiple specific interactions, suggesting a potential protein target for its antibacterial activity^[1].
Antibacterial agent 349 (25-200 mg/L; 12 h) differentially regulates antioxidant enzyme activities in Xanthomonas oryzae pv oryzicola (Xoc), inhibiting CAT and SOD while upregulating GR in a concentration-dependent manner^[1].
Antibacterial agent 349 (50-200 mg/L) induces substantial proteomic reprogramming in Xanthomonas oryzae pv oryzicola (Xoc), altering 130 proteins to disrupt bacterial metabolic homeostasis^[1].
Antibacterial agent 349 (25-200 mg/L) concentration-dependently activates citrate synthase and isocitrate dehydrogenase in Xanthomonas oryzae pv oryzicola (Xoc), disrupting normal TCA cycle feedback regulation and metabolic homeostasis^[1].

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