H-D-Tpi-OH  (Synonyms: D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid)

H-D-Tpi-OH (D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid) is a tetrahydro-β-carboline derivative. H-D-Tpi-OH only slightly upregulates QR1, mildly inhibits the aromatase and NO synthesis pathways, and shows no significant in vitro anti-breast tumor proliferation activity. H-D-Tpi-OH can be used in cancer-related research^[1].

H-D-Tpi-OH (compound 1b) only exhibits weak QR1-inducing activity (IR=0.8), 34.9% aromatase inhibitory effect and 3.5% nitric oxide production inhibition, and lacks significant NF-κB inhibitory activity and MCF7 cell proliferation inhibitory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

216.24

C₁₂H₁₂N₂O₂

72002-54-1

C(O)(=O)[C@H]1CC=2C=3C(NC2CN1)=CC=CC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shen L, et al. Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. Bioorg Med Chem. 2011;19(21):6182-6195.  [Content Brief]