10-Formylfolic acid
Based on 1 Customer Validation
10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions.
For research use only. We do not sell to patients.
- Purity: 94.49%
- CAS No.: 134-05-4
- Formula: C20H19N7O7
- Molecular Weight:469.41
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
10-Formylfolic acid (80 nM; 2 min) potently inhibits purified rat liver dihydrofolate reductase with an IC50 of 80 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
10-Formylfolic acid (92 pmol/kg body weight; oral; single dose) is absorbed and metabolized in healthy Sprague Dawley rats in a manner quantitatively and qualitatively similar to folic acid, with 10.3% of the oral dose recovered as hepatic 5-methyltetrahydrofolic acid at 24 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cobb × Cobb (male, day-old, folacin-deficient model)[1]
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Dosage:1.60 nmol/g of diet
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Administration:oral; ad libitum; 21 days
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Result:Achieved a mean weight gain of 523 g.
Achieved a mean feed consumption of 32.9 g per chick per day.
Achieved a mean plasma folacin concentration of 14.7 ng/mL.
Exhibited 97.5% folacin activity relative to folic acid based on plasma folacin dose-response curve analysis.
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Animal Model:Crl:CD(SD)BR Sprague Dawley (male, 500-600 g, normal healthy)[1]
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Dosage:92 pmol/kg body weight
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Administration:oral; single dose
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Result:Resulted in 10.3% of the oral dose recovered as hepatic 5-methyltetrahydrofolic acid 24 hours after dosing.
Produced a relative distribution of radiolabeled hepatic folates: 25% tetrahydrofolic acid, 63% 5-methyltetrahydrofolic acid, and 12% 5-formyltetrahydrofolic acid.
Chemical Information
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CAS No. 134-05-4
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Appearance Solid
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Molecular Weight 469.41
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Formula C20H19N7O7
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Color Light yellow to brown
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SMILES
O=C(O)[C@@H](NC(C1=CC=C(N(C=O)CC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O)CCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (286 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
10-Formylfolic acid Related Classifications
HY-124350 Related Classifications
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