134-05-4
Chemical Structure
10-Formylfolic acid
- CAS 番号: 134-05-4
- Formula:C20H19N7O7
- Molecular Weight:469.41
IUPAC Name: (4-(N-((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzoyl)-L-glutamic acid
InChIKey: UGWUWNVTCLDEOG-ZDUSSCGKSA-N
SMILES: O=C(O)[C@@H](NC(C1=CC=C(N(C=O)CC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O)CCC(O)=O
Biological Activity: 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions[1][2][3].
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10-Formylfolic acid | 94.49% | 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions. | ||||||||||||||||||||
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10-Formylfolic acid (Standard) | ≥98% | 10-Formylfolic acid (Standard) is the analytical standard of 10-Formylfolic acid (HY-124350). This product is intended for research and analytical applications. 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions. | ||||||||||||||||||||
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10-Formylfolic acid-d4 | 10-Formylfolic acid-d4 is the deuterated-labeled 10-Formylfolic acid (HY-124350). 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions. | |||||||||||||||||||||
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References
- [1]. Gregory JF III, et al. Biological activity of the folacin oxidation products 10‑formylfolic acid and 5‑methyl‑5,6‑dihyrofolic acid. J Agric Food Chem. 1984;32(6):1337‑1342.
- [2]. D'Urso-Scott M, et al. Formation of 10-formylfolic acid, a potent inhibitor of dihydrofolate reductase, in rat liver slices incubated with folic acid. Proceedings of the National Academy of Sciences of the United States of America. 1974 Jul;71(7):2736-9. [Content Brief]
- [3]. Ashokkumar K, et al. Identification and determination of naturally occurring folates in grains of rice (Oryza sativa L.) by UPLC-MS/MS analysis. Natural product research. 2018 Jul;32(14):1733-1737.
