country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-183053

Copy Link Print Information

UCP1173

UCP1173, propargyl-linked antifolate, is an antibacterial agent. UCP1173 inhibits DHFR enzymes, with IC₅₀ values of 0.014 μM for DfrB, 0.19 μM for DfrG, 0.27 μM for DfrA, and 0.091 μM for DfrK. UCP1173 inhibits growth of Staphylococcus aureus clinical isolates carrying dfrA, dfrG, or dfrK resistance genes. UCP1173 can be used for the research of bacterial infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1922152-09-7
分子式: C₂₄H₂₄N₄O₃
分子量:416.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

UCP1173 構造式

CAS 番号: 1922152-09-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	100 μM Compound: 11S	Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay	[PMID: 27437079]

体外実験

UCP1173 potently inhibits the growth of Trimethoprim (HY-B0510)-resistant MRSA/MSSA isolates carrying dfrG, dfrA, or dfrK, with MIC values ranging from 1.25 to 5 μg/mL for resistant strains, and shows high activity against wild-type ATCC 43300 S. aureus with an MIC of 0.0098 μg/mL^[1].
UCP1173 potently inhibits wild-type and TMP-resistant S. aureus DHFR enzymes, with IC₅₀ values of 0.014 μM for DfrB, 0.19 μM for DfrG, 0.27 μM for DfrA, and 0.091 μM for DfrK^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1922152-09-7
分子量 416.48
分子式 C₂₄H₂₄N₄O₃
SMILES

[C@H](C#CC=1C(CC)=NC(N)=NC1N)(C)C=2C=C(C=C(OC)C2)C3=CC=C(C(O)=O)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Reeve SM, et al. MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol. 2016;23(12):1458-1467. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

お問い合わせ在庫あり