1922152-09-7
Chemical Structure
UCP1173
- CAS No.: 1922152-09-7
- Formula:C24H24N4O3
- Molecular Weight:416.48
IUPAC Name: (S)-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid
InChIKey: OKJCHFXBCVXSIZ-CQSZACIVSA-N
SMILES: [C@H](C#CC=1C(CC)=NC(N)=NC1N)(C)C=2C=C(C=C(OC)C2)C3=CC=C(C(O)=O)C=C3
Biological Activity: UCP1173, propargyl-linked antifolate, is an antibacterial agent. UCP1173 inhibits DHFR enzymes, with IC50 values of 0.014 μM for DfrB, 0.19 μM for DfrG, 0.27 μM for DfrA, and 0.091 μM for DfrK. UCP1173 inhibits growth of Staphylococcus aureus clinical isolates carrying dfrA, dfrG, or dfrK resistance genes. UCP1173 can be used for the research of bacterial infections[1].
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UCP1173 | UCP1173, propargyl-linked antifolate, is an antibacterial agent. UCP1173 inhibits DHFR enzymes, with IC50 values of 0.014 μM for DfrB, 0.19 μM for DfrG, 0.27 μM for DfrA, and 0.091 μM for DfrK. UCP1173 inhibits growth of Staphylococcus aureus clinical isolates carrying dfrA, dfrG, or dfrK resistance genes. UCP1173 can be used for the research of bacterial infections. | |||||||||||||||||||||
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Keywords
