PTGR1 Antibody (YA6993)
(Synonyms: 15-oxoprostaglandin 13-reductase antibody; FLJ99229 antibody; leukotriene B4 12-hydroxydehydrogenase antibody; LTB4DH antibody; MGC34943 antibody; NADP-dependent leukotriene B4 12-hydroxydehydrogenase antibody; PGR1 antibody; PRG-1 antibody; Prostaglandin reductase 1 antibody; Ptgr1 antibody)
Based on 1 Customer Validation
PTGR1 Antibody (YA6993) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PTGR1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:1000 | 1:1000 |
Product Details
PTGR1 Antibody (YA6993) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PTGR1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 36 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 36 kDa
Recombinant protein within human PTGR1 aa 1-329 / 329.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PTGR1 is a NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles[1].
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: High expression in the kidney, liver, and intestine but not in leukocytes -
Isoforms & Post-Translational Modification
Q14914 has two isomers: Q14914-1: 35870 Da (predicted); Q14914-2: 32895 Da (predicted).
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Subunit
Monomer or homodimer
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SwissProt ID
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Synonyms
15-oxoprostaglandin 13-reductase antibody; FLJ99229 antibody; leukotriene B4 12-hydroxydehydrogenase antibody; LTB4DH antibody; MGC34943 antibody; NADP-dependent leukotriene B4 12-hydroxydehydrogenase antibody; PGR1 antibody; PRG-1 antibody; Prostaglandin reductase 1 antibody; Ptgr1 antibody
Documentation
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Data Sheet (231 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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User Guide for Antibodies (1077 KB)
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