Zinc sulphate
Based on 1 publication(s) in Google Scholar
Zinc sulphate is an orally active inhibitor of tyrosinase and glutathione reductase. Zinc sulphate enhances the activity of dopachrome tautomerase. Zinc sulphate delays anagen-related eumelanin production, induces hair hypopigmentation in mice, and accelerates wound healing. Zinc sulphate can be used in research related to benign gastric ulcers. Zinc sulphate can be used in research related to rheumatoid arthritis.
For research use only. We do not sell to patients.
- Purity : 99.85%
- CAS No.: 7733-02-0
- Formula: ZnSO4
- Molecular Weight:161.44
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Zinc sulphate
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Customer Validation & Images
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Cell Proliferation/Viability Assay
Biological Activity
Description
In Vitro
Zinc inhibits tyrosinase and glutathione reductase in vitro, but also enhances the activity of dopachrome tautomerase and acts as an agonist of melanocortin receptor signaling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 a/a (female, 6-8 weeks old)[1]
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Dosage:20 mg/mL
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Administration:oral; continuous; up to 11 months
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Result:Observed macroscopic bright brown lightening of new hair shafts produced during anagen, with the effect maintained throughout the treatment period.
Confirmed no switch from eumelanogenesis to phaeomelanogenesis via EPR analysis.
Reduced and poorly pigmented melanin granules in precortical hair matrix keratinocytes, hair bulb melanocytes, and hair shafts compared with controls.
Maintained hair coat lightening usually persisted until the immediately consecutive anagen phase after treatment discontinuation.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 7733-02-0
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Appearance Solid
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Molecular Weight 161.44
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Formula ZnSO4
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Color White to off-white
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SMILES
O=S(=O)=[Zn](=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (1)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Colistin-induced acute kidney injury via zinc Dyshomeostasis-triggered GSDMD-executed Pyroptosis. [Abstract]2026 Jan 1;168(Pt 1):115768. PMID: 41176907
Zinc sulphate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115768. [Abstract]
Viability assays demonstrating TPEN cytoprotection and ZnSO4 (Zinc sulphate; 115 μM; 24 h) -aggravated injury in colistin-exposed HK-2 cells.
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (309.71 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Collagen-Induced Arthritis
Collagen-induced arthritis (CIA) is an autoimmune murine model of rheumatoid arthritis in which immunization with type II collagen (CII) emulsified in an adjuvant induces a T cell- and autoantibody-driven inflammatory arthritis characterized by synovial hyperplasia, immune cell infiltration, and joint destruction. The model typically relies on genetically susceptible mouse strains (e. g. , DBA/1) and reproduces key features of human rheumatoid arthritis, including anti-collagen immune responses and progressive joint inflammation. Disease onset generally occurs within ~3-4 weeks after immunization, depending on antigen/adjuvant combinations and protocol variation. The immunopathology is driven by adaptive immune activation against CII, leading to systemic and local joint inflammation mediated by pro-inflammatory cytokines and effector immune cells, making CIA a standard preclinical platform for evaluating immunomodulatory and anti-arthritic interventions.
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Cell migration
Cell migration is a method that plays an important role in wound healing, cell differentiation, embryonic development, etc.
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Cell-Exclusion Zone Migration Assay
The Cell-Exclusion Zone (CEZ) migration assay is an in vitro 2D cell migration method in which a defined cell-free area is created using removable physical barriers such as silicone stoppers, allowing cells to be seeded around the barrier and subsequently migrate into the cleared zone after barrier removal. This approach enables quantification of collective cell migration by monitoring repopulation of the initially cell-free region over time using microscopy-based imaging. Compared with scratch-based wound healing assays, barrier-based exclusion methods are designed to avoid mechanical damage to the extracellular matrix and reduce injury-induced effects on boundary cells, thereby improving interpretability of migration behavior in vitro. The assay readout is typically the progressive reduction in the cell-free area or the number of cells invading the exclusion zone, reflecting coordinated cell motility relevant to physiological processes such as wound healing, epithelial repair, and ca
Purity & Documentation
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Data Sheet (276 KB)
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SDS (620 KB)
- English - EN (620 KB)
- Français - FR (620 KB)
- Deutsch - DE (620 KB)
- Norwegian - NO (620 KB)
- Español - ES (620 KB)
- Swedish - SV (620 KB)
- Italian - IT (620 KB)
- Korean - KR (620 KB)
- Portuguese - PT (620 KB)
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Handling Instructions (2659 KB)
References
[1]. Plonka PM, et al. Oral zinc sulphate causes murine hair hypopigmentation and is a potent inhibitor of eumelanogenesis in vivo. Br J Dermatol. 2006;155(1):39-49. [Content Brief]
[2]. Frommer DJ, et al. The healing of gastric ulcers by zinc sulphate. Med J Aust. 1975;2(21):793-796. [Content Brief]
[3]. Simkin PA, et al. Oral zinc sulphate in rheumatoid arthritis. Lancet. 1976;2(7985):539-542. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.1943 mL | 30.9713 mL | 61.9425 mL | 154.8563 mL |
| 5 mM | 1.2389 mL | 6.1943 mL | 12.3885 mL | 30.9713 mL | |
| 10 mM | 0.6194 mL | 3.0971 mL | 6.1943 mL | 15.4856 mL | |
| 15 mM | 0.4130 mL | 2.0648 mL | 4.1295 mL | 10.3238 mL | |
| 20 mM | 0.3097 mL | 1.5486 mL | 3.0971 mL | 7.7428 mL | |
| 25 mM | 0.2478 mL | 1.2389 mL | 2.4777 mL | 6.1943 mL | |
| 30 mM | 0.2065 mL | 1.0324 mL | 2.0648 mL | 5.1619 mL | |
| 40 mM | 0.1549 mL | 0.7743 mL | 1.5486 mL | 3.8714 mL | |
| 50 mM | 0.1239 mL | 0.6194 mL | 1.2389 mL | 3.0971 mL | |
| 60 mM | 0.1032 mL | 0.5162 mL | 1.0324 mL | 2.5809 mL | |
| 80 mM | 0.0774 mL | 0.3871 mL | 0.7743 mL | 1.9357 mL | |
| 100 mM | 0.0619 mL | 0.3097 mL | 0.6194 mL | 1.5486 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Zinc sulphate Related Classifications
HY-B1820 Related Classifications
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Keywords
- Zinc sulphate
- 7733-02-0
- Environmental Pollutants
- Tyrosinase
- Glutathione Reductase (GR)
- Biochemical Assay Reagents
- eumelanogenesis
- melanocortin receptor 1
- hair follicle cycling
- tyrosinase
- glutathione reductase
- rheumatoid arthritis
- Cu,Zn-superoxide dismutase
- dopachrome tautomerase
- benign gastric ulcers
- melanocortin receptor 4
- Inhibitor
- inhibitor
- inhibit