Zinc sulphate

Name: Zinc sulphate
Brand: MedChemExpress
SKU: HY-B1820
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1820 Purity: 99.85%: Data Sheet
COA

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Handling Instructions
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Zinc sulphate is an orally active inhibitor of tyrosinase and glutathione reductase. Zinc sulphate enhances the activity of dopachrome tautomerase. Zinc sulphate delays anagen-related eumelanin production, induces hair hypopigmentation in mice, and accelerates wound healing. Zinc sulphate can be used in research related to benign gastric ulcers. Zinc sulphate can be used in research related to rheumatoid arthritis.

For research use only. We do not sell to patients.

Zinc sulphate Chemical Structure

CAS No. : 7733-02-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Zinc sulphate

•Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115768. [Abstract]

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Description

In Vitro

Zinc inhibits tyrosinase and glutathione reductase in vitro, but also enhances the activity of dopachrome tautomerase and acts as an agonist of melanocortin receptor signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zinc sulphate (20 mg/mL; administered orally via drinking water; continuous; up to 11 months) induces a persistent lightening of hair shafts to a bright brown color during the natural anagen phase of mouse hair, inhibits eumelanin production without switching to pheomelanin production, and reduces the density of melanin granules in hair follicle structures^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 a/a (female, 6-8 weeks old)^[1]
Dosage:	20 mg/mL
Administration:	oral; continuous; up to 11 months
Result:	Observed macroscopic bright brown lightening of new hair shafts produced during anagen, with the effect maintained throughout the treatment period. Confirmed no switch from eumelanogenesis to phaeomelanogenesis via EPR analysis. Reduced and poorly pigmented melanin granules in precortical hair matrix keratinocytes, hair bulb melanocytes, and hair shafts compared with controls. Maintained hair coat lightening usually persisted until the immediately consecutive anagen phase after treatment discontinuation.

Clinical Trial

Molecular Weight

161.44

Formula

ZnSO₄

CAS No.

7733-02-0

Appearance

Solid

Color

White to off-white

SMILES

O=S(=O)=[Zn](=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (309.71 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1943 mL	30.9713 mL	61.9425 mL
5 mM	1.2389 mL	6.1943 mL	12.3885 mL
10 mM	0.6194 mL	3.0971 mL	6.1943 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.85%

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Data Sheet (276 KB) SDS (620 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Plonka PM, et al. Oral zinc sulphate causes murine hair hypopigmentation and is a potent inhibitor of eumelanogenesis in vivo. Br J Dermatol. 2006;155(1):39-49. [Content Brief]

[2]. Frommer DJ, et al. The healing of gastric ulcers by zinc sulphate. Med J Aust. 1975;2(21):793-796. [Content Brief]

[3]. Simkin PA, et al. Oral zinc sulphate in rheumatoid arthritis. Lancet. 1976;2(7985):539-542. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.1943 mL	30.9713 mL	61.9425 mL	154.8563 mL
	5 mM	1.2389 mL	6.1943 mL	12.3885 mL	30.9713 mL
	10 mM	0.6194 mL	3.0971 mL	6.1943 mL	15.4856 mL
	15 mM	0.4130 mL	2.0648 mL	4.1295 mL	10.3238 mL
	20 mM	0.3097 mL	1.5486 mL	3.0971 mL	7.7428 mL
	25 mM	0.2478 mL	1.2389 mL	2.4777 mL	6.1943 mL
	30 mM	0.2065 mL	1.0324 mL	2.0648 mL	5.1619 mL
	40 mM	0.1549 mL	0.7743 mL	1.5486 mL	3.8714 mL
	50 mM	0.1239 mL	0.6194 mL	1.2389 mL	3.0971 mL
	60 mM	0.1032 mL	0.5162 mL	1.0324 mL	2.5809 mL
	80 mM	0.0774 mL	0.3871 mL	0.7743 mL	1.9357 mL
	100 mM	0.0619 mL	0.3097 mL	0.6194 mL	1.5486 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Zinc sulphate Related Classifications

Metabolic Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Zinc sulphate

Customer Review

Zinc sulphate Related Antibodies

1 Publications Citing Use of MCE Zinc sulphate

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•Related Small Molecules:

•Related Proteins:

Biological Activity

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References

Customer Review

Zinc sulphate Related Antibodies

Molarity Calculator

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Complete Stock Solution Preparation Table

Zinc sulphate Related Classifications

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