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TP-TRFS 

Cat. No.: HY-D1253
Handling Instructions

TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR).

For research use only. We do not sell to patients.

TP-TRFS Chemical Structure

TP-TRFS Chemical Structure

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Description

TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR)[1].

In Vitro

TP-TRFS (10 μM) exhibits weak fluorescence (Φ = 0.57%, absolute quantum yield), and after TP-TRFS (10 μM)) is incubated with TCEP (1 mM), a dramatic fluorescence increment at 490 nm is observed (Φ= 22.31%, absolute quantum yield) and the fluorescence intensity of the test system increased by B40-fold within 3 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TP-TRFS has the ability to visualize the TrxR activity in vivo, and also provides a mechanistic link between stroke and the loss of TrxR function, which may open up a new therapeutic window of stroke via the regulation of TrxR function[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

333.43

Formula

C₁₆H₁₅NO₃S₂

SMILES

CC(C1=CC=C2C=C(C=CC2=C1)NC(OC3CSSC3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TP-TRFSOthersThioredoxinreductasestrokeInhibitorinhibitorinhibit

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TP-TRFS
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