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Ai ling tan parp Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PARP (177) ADC Cytotoxin (1) ADC Linker (2) Adenosine Receptor (1) Akt (2) Aldehyde Dehydrogenase (ALDH) (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (2) Antibiotic (7) Apoptosis (85) Aryl Hydrocarbon Receptor (1) ATM/ATR (1) Autophagy (16) Bacterial (7) Bcl-2 Family (11) c-Met/HGFR (1) c-Myc (1) Caspase (19) CDK (6) CFTR (1) CGRP Receptor (1) Checkpoint Kinase (Chk) (1) Dipeptidyl Peptidase (1) DNA-PK (1) DNA/RNA Synthesis (2) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) Dynamin (1) E3 Ligase Ligand-Linker Conjugates (4) EGFR (2) Endogenous Metabolite (17) Endothelin Receptor (1) Epigenetic Reader Domain (4) Eukaryotic Initiation Factor (eIF) (3) Fatty Acid Synthase (FASN) (1) FGFR (2) HDAC (7) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) Histone Methyltransferase (2) HIV (1) IAP (1) IGF-1R (1) Influenza Virus (1) IRAK (1) Isotope-Labeled Compounds (6) JNK (1) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (1) MicroRNA (4) Microtubule/Tubulin (7) Mitophagy (4) Molecular Glues (2) Necroptosis (1) Nucleoside Antimetabolite/Analog (7) Opioid Receptor (1) P-glycoprotein (3) p38 MAPK (5) Parasite (5) Phosphatase (3) Phosphodiesterase (PDE) (1) PI3K (2) Poly(ADP-ribose) Glycohydrolase (PARG) (2) Potassium Channel (7) PPAR (3) PROTAC Linkers (4) PROTACs (7) Proteasome (1) RAR/RXR (3) Reactive Oxygen Species (2) Reverse Transcriptase (1) ROS Kinase (1) Sirtuin (5) Small Interfering RNA (siRNA) (25) STAT (2) Survivin (1) Target Protein Ligand-Linker Conjugates (1) Topoisomerase (2) VEGFR (3)
By Research Areas:	Cancer (233) Cardiovascular Disease (8) Infection (13) Inflammation/Immunology (25) Metabolic Disease (8) Neurological Disease (24)
Click Chemistry:	PROTAC Synthesis (1) Azide (3) Alkynes (2)

322

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: PARP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136208

TAN-452	Opioid Receptor	Neurological Disease
TAN-452 is an orally active, selective peripherally acting δ-opioid receptor (DOR) antagonist with a K_i of 0.47 nM and a K_b of 0.21 nM. TAN-452 is an antagonist for μ-opioid receptor (MOR; K_i=36.56 nM and K_b=9.43 nM) and κ-opioid receptor (KOR; K_i=5.31 nM and K_b=7.18 nM). TAN-452, a derivative of Naltrindole, demonstrates low brain penetrability and attenuates morphine-induced side effects without affecting pain control .

HY-101317

TAN-67 dihydrobromide SB-205607 dihydrobromide
TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a K_i value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke .

HY-128488

Antibiotic TAN-592B

Bacterial Antibiotic Infection

Antibiotic TAN-592B is an antibiotic against infectious disease caused by bacteria .

*Antibiotic TAN-592B*	Bacterial Antibiotic	Infection
Antibiotic TAN-592B is an antibiotic against infectious disease caused by bacteria .

HY-107736

AI-3	Others	Inflammation/Immunology Cancer
AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases .

HY-157490

PARP/HDAC-IN-1	PARP HDAC	Cancer
PARP/HDAC-IN-1 (compound B102) is a potent dual inhibitor of *PARP* and HDAC. PARP/HDAC-IN-1 inhibits *PARP1, PARP2* and HDAC1 with IC₅₀s of 19.01, 2.13, 1690 nM, respectively .

HY-157165

*Tubulin/PARP-IN-1*	Microtubule/Tubulin PARP	Cancer
Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. *Tubulin/PARP*-IN-1 inhibits PARP and tubulin with IC₅₀s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase .

HY-16786

AI-10-49	Others	Inflammation/Immunology Cancer
AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC₅₀ value of 0.26 μM. AI-10-49 can be used for the research of leukemia .

HY-111134

TAN 420C

Antibiotic Infection Cancer

TAN 420C is an antibiotic that shows a strong cytotoxic activity against the lymphocytic leukemia .

TAN 420C	Antibiotic	Infection Cancer
TAN 420C is an antibiotic that shows a strong cytotoxic activity against the lymphocytic leukemia .

HY-125218

PARP11 inhibitor ITK7 ITK7	PARP	Cancer
PARP11 inhibitor ITK7 (ITK7) is a potent and selective *PARP11* inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC₅₀ value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization . PARP11 inhibitor ITK7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-122657

AI-10-104

Others Cancer

AI-10-104 is an inhibitor for runt-related transcription factor (RUNX), which enhances the cytotoxicity in myeloma cells .
HY-138617

AI-10-47

Others Cancer

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC₅₀ of 3.2 μM .

AI-10-104	Others	Cancer
AI-10-104 is an inhibitor for runt-related transcription factor (RUNX), which enhances the cytotoxicity in myeloma cells .

AI-10-47	Others	Cancer
AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC₅₀ of 3.2 μM .

HY-141486A

*PROTAC PARP/EGFR ligand 1*	PARP EGFR Ligands for Target Protein for PROTAC	Others
PROTAC PARP/EGFR ligand 1 is an active compound that can be used for the synthesis of dual PARP EGFR degraders by proteolytic targeting chimera (PROTAC) technology .

HY-R01642

hsa-miR-548ai mimic	MicroRNA	Cancer
hsa-miR-548ai mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-548ai mimic hsa-miR-548ai mimic

HY-121300

Kendomycin (-)-tan2162	Antibiotic Bacterial Endothelin Receptor CGRP Receptor	Infection Cancer
Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent .

HY-157137

PARP1-IN-17	PARP Caspase Apoptosis	Cancer
PARP1-IN-17 is a *PARP-1* inhibitor (IC₅₀ = 19.24 nM for *PARP-1* and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity .

HY-153590

PARP-1-IN-4	PARP	Cancer
PARP-1-IN-4 is a *PARP-1* inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC₅₀ value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma .

HY-149800

PARP-1-IN-3	PARP Apoptosis Caspase	Cancer
PARP-1-IN-3, a benzamide derivative, is a potent *PARP-1* inhibitor with IC₅₀ values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer .

HY-RI01642

hsa-miR-548ai inhibitor	MicroRNA
hsa-miR-548ai inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-548ai inhibitor hsa-miR-548ai inhibitor

HY-148754

PARP10-IN-3	PARP	Cancer
PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase *PARP10* inhibitor with an IC₅₀ of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on *PARP2* and *PARP15* with IC₅₀s of 1.7 μM for human PARP2 and human PARP15, respectively .

HY-D1188

PARP7-probe-1	PARP	Cancer
PARP7-probe-1 is a chemiluminescent labeled *PARP7* probe. PARP7-probe-1 is a biotinylated probe binding to the PARP7 active site. PARP7-probe-1 can be used for the research of PARP7 function .

HY-148753

PARP10-IN-2	PARP	Cancer
PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase *PARP10* inhibitor with an IC₅₀ of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on *PARP2* and *PARP15* with IC₅₀s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively .

HY-151625

PARP-2-IN-3	PARP Apoptosis	Cancer
PARP-2-IN-3 (Compound 12) is a potent *PARP-2* inhibitor with an IC₅₀ of 0.07 μM. PARP-2-IN-3 induces apoptosis and necrosis in cancer cells. PARP-2-IN-3 shows appropriate predicted pharmacokinetic parameters and oral bioavailability .

HY-102035

PARP-2-IN-1

PARP Cancer

PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC₅₀ of 11.5 nM.

PARP-2-IN-1	PARP	Cancer
PARP-2-IN-1 is a potent and selective *PARP-2* inhibitor with an IC₅₀ of 11.5 nM.

HY-132297A

PARP1-IN-5 dihydrochloride 1 Publications Verification	PARP	Cancer
PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective *PARP-1* inhibitor (IC₅₀ =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer .

HY-132297

PARP1-IN-5

PARP Cancer

PARP1-IN-5 is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC₅₀ =14.7 nM). PARP1-IN-5 can be used for the research of cancer .

PARP1-IN-5	PARP	Cancer
PARP1-IN-5 is a low toxicity, orally active, potent and selective *PARP-1* inhibitor (IC₅₀ =14.7 nM). PARP1-IN-5 can be used for the research of cancer .

HY-147886

PARP1-IN-11	PARP	Cancer
PARP1-IN-11 (compound 49) is a potent *PARP1* inhibitor with IC₅₀ value of 0.082 µM. PARP1-IN-11 shows complete inhibition of PARP2 and substantially inhibits PARP3, TNKS1 and TNKS2 .

HY-151624

PARP-2-IN-2	PARP Apoptosis	Cancer
PARP-2-IN-2 (compound 27) is a *PARP‑2* inhibitor with an IC₅₀ value of 0.057 µM. PARP-2-IN-2 induces cell cycle arrest and apoptosis of MCF-7 breast cancer cells. PARP-2-IN-2 can be used for the research of cancer .

HY-155246

PARP1-IN-15	Apoptosis PARP	Cancer
PARP1-IN-15 (Compound 6) is a *PARP1* inhibitor. PARP1-IN-15 inhibits tankyrase (TNKS) and facilitates DNA double-strand breaks damage. PARP1-IN-15 induces tumor cell apoptosis. PARP1-IN-15 has anti-cancer activity in triple-negative breast cancer (TNBC) cells and TNBC patient-derived organoids. PARP1-IN-15 can be used for research of TNBC with or without BRCA1 mutations .

HY-155122

PARP-1-IN-13	PARP	Cancer
PARP-1-IN-13 (Compound 19c) is a *PARP-1* inhibitor (IC₅₀: 26 nM). PARP-1-IN-13 inhibits DNA single-strand breakage repair and aggravates DNA double-strand breakage. PARP-1-IN-13 promotes the apoptosis of cancer cells through the mitochondrial apoptosis pathway .

HY-105253

PARP-2/1-IN-2	PARP	Neurological Disease
PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent *PARP* inhibitor with K_is of 2 and 5 nM against *PARP-2* and *PARP-1, respectively. PARP-2/1-IN-2 has an EC₅₀ of 3 nM in a cell based assay of PARP* activity .

HY-151609

PARP7-IN-12

PARP Cancer

PARP7-IN-12 is a potent PARP7 Inhibitor with an IC₅₀ value of 7.836 nM. PARP7-IN-12 can be used in research of cancer .
HY-163081

PARP7-IN-17

PARP Cancer

PARP7-IN-17 is a potent inhibitor of PARP7 with IC₅₀ of 4.5 nM that has oral bioavailability. PARP7-IN-17 displays antitumor effect .
HY-162114

PARP1-IN-18

PARP Cancer

PARP1-IN-18 (compound 25) is a potent PARP1 inhibitor with an IC₅₀ value of 2.7 nM. PARP1-IN-18 has anticancer effects .

PARP7-IN-12	PARP	Cancer
PARP7-IN-12 is a potent *PARP7* Inhibitor with an IC₅₀ value of 7.836 nM. PARP7-IN-12 can be used in research of cancer .

PARP7-IN-17	PARP	Cancer
PARP7-IN-17 is a potent inhibitor of *PARP7* with IC₅₀ of 4.5 nM that has oral bioavailability. PARP7-IN-17 displays antitumor effect .

PARP1-IN-18	PARP	Cancer
PARP1-IN-18 (compound 25) is a potent *PARP1* inhibitor with an IC₅₀ value of 2.7 nM. PARP1-IN-18 has anticancer effects .

HY-149001

PARP1-IN-9	PARP	Cancer
PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC₅₀ of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) .

HY-162172

PARP7-IN-18	PARP	Cancer
Parp7-in-18 (Compund 8) is a selective *PARP7* inhibitor with an IC₅₀ of 0.11 nM. PARP7-IN-18 exhibits good anticancer activity and pharmacokinetic properties .

HY-144642

PARP-1-IN-1	PARP	Cancer
PARP-1-IN-1 is a high selective and orally active *PARP-1* inhibitor (IC₅₀=0.96 nM). PARP-1-IN-1 has well tolerance and remarkable single dose activity in the MDA-MB-436 xenotransplantation model .

HY-147027

PARP-1-IN-2	PARP Caspase Apoptosis	Cancer
PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated *PARP1* inhibitor, with an IC₅₀ of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis .

HY-156419

PARP7-IN-16	PARP	Cancer
PARP7-IN-16 (compound 36) is a potent, selective and orally active inhibitor of *PARP-1/2/7, with IC₅₀s of 0.94, 0.87 and 0.21 nM, respectively. PARP*7-IN-16 can be used for the research of breast cancer and prostate cancer .

HY-146502

PARP10/15-IN-3	PARP Apoptosis	Cancer
PARP10/15-IN-3 (Compound 8a) is a potent *PARP10* and *PARP15* dual inhibitor with IC₅₀ values of 0.14 µM and 0.40 µM against PARP10 and PARP15, respectively. PARP10/15-IN-3 is able to enter cells and rescue cells from apoptosis .

HY-150765

PARP1-IN-12	PARP Apoptosis	Cancer
PARP1-IN-12 is a potent *PARP1* inhibitor with an IC₅₀ of 2.99 nM. PARP1-IN-12 exhibits antiproliferative activity, can induce cell apoptosis and cause cycle arrest at G2/M phase. PARP1-IN-12 also can induce DNA double strand breaks (DSBs) in BRCA-deficient cells .

HY-156298

PARP1-IN-16	PARP Apoptosis	Cancer
PARP1-IN-16 (compound 12a) is a potent *PARP1* inhibitor, with an IC₅₀ of 1.89 nM. PARP1-IN-16 can arrest the cell cycle in S phase and induce apoptosis in HCT-116 cells .

HY-146501

PARP10/15-IN-2	PARP Apoptosis	Cancer
PARP10/15-IN-2 (Compound 8h) is a potent *PARP10* and *PARP15* dual inhibitor with IC₅₀ values of 0.15 µM and 0.37 µM against PARP10 and PARP15, respectively. PARP10/15-IN-2 is able to enter cells and rescue cells from apoptosis .

HY-157320

*Tubulin/PARP-IN-2*	Microtubule/Tubulin Apoptosis	Cancer
Tubulin/PARP-IN-2 (compound 14) is a dual *PARP-Tubulin* inhibitor. Tubulin/PARP-IN-2 inhibits PARP1, PARP2, and tubulin activity with IC₅₀ values of 74 nM, 109 nM, and 1.4 µM, respectively. Tubulin/PARP-IN-2 induces apoptosis as well as autophagy. Tubulin/PARP-IN-2 causes cell cycle arrest at the G2/M phase .

HY-160417

PARP1-IN-19

PARP Cancer

PARP1-IN-19 is a PARP1 inhibitor with antitumor effects (CN107955001A; Embodiment 3) .

PARP1-IN-19	PARP	Cancer
PARP1-IN-19 is a *PARP1* inhibitor with antitumor effects (CN107955001A; Embodiment 3) .

HY-143398

PARP10/15-IN-1	PARP	Cancer
PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of *PARP10* and *PARP15, with IC₅₀s of 160 nM and 370 nM, respectively. PARP*10/15-IN-1 can be used for cancer .

HY-142657

PARP1-IN-7

PARP Cancer

PARP1-IN-7 is an inhibitor of poly(ADP-ribose) polymerase-1 (PARP1) as an anticancer agent.
HY-145328

PARP-1/2-IN-1

PARP Others

PARP-1/2-IN-1 is a potent PARP-1/2 inhibitor with IC₅₀ of 0.51 nM and 23.11 nM, respectively.

PARP1-IN-7	PARP	Cancer
PARP1-IN-7 is an inhibitor of poly(ADP-ribose) polymerase-1 (PARP1) as an anticancer agent.

HY-147030

PARP1-IN-8	PARP	Cancer
PARP1-IN-8 (compound 11c) is a potent and BBB-penetrated *PARP1* inhibitor, with an IC₅₀ of 97 nM. PARP1-IN-8 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549 .

HY-R01642A

hsa-miR-548ai agomir	MicroRNA
hsa-miR-548ai agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-548ai agomir hsa-miR-548ai agomir

HY-155351

PARP7-IN-15

PARP Cancer

PARP7-IN-15 (Compound 18) is a PARP7 inhibitor with IC₅₀ of 0.56 nM, that has antitumor activity .

Cat. No.	Product Name

HY-L173

Anti-Ovarian Cancer Compound Library

1883 Compounds compounds

Ovarian cancer is the most common cause of death in female genital malignancies, with the highest mortality rate in female genital malignancies. It is characterized by difficulty in detection in the early stage of the disease, high recurrence rate and poor prognosis. In fact, ovarian cancer includes many pathologic types. It is usually divided into epithelial ovarian cancer, malignant germ cell tumors and sex cord stromal tumors, of which epithelial ovarian cancer is the most dominant form. Clinical treatment of ovarian cancer prioritizes surgery combined with paclitaxel chemotherapy. However, due to the spread and drug resistance of tumor cells, the recurrence of ovarian cancer is high. In this case, combined with traditional methods, the development of new therapeutic agents can help to improve the treatment effect of ovarian cancer.

MCE designs a unique collection of 1883 compounds with definite or potential anti-ovarian cancer activity, which mainly targeting the main targets of ovarian cancer such as PARP, ATM/ATR, VEGFR and HIF/HIF Prolyl-Hydroxylase, etc. It is an essential tool for development and research of anti-ovarian compounds.

HY-L0113V

1M Drug Fragment-Based Diversity Library	1,000,000 compounds
A diversity compound library contains 1,000,000 compounds with drug fragments. Each compound has at least one drug fragment. These selected molecules have 702,902 Bemis-Murcko Scaffolds (BMS) with drug-like chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.

HY-L912V

MegaUni 10M Virtual Diversity Library

10,000,000 compounds

With MCE's 40,662 BBs, covering around 273 reaction types, more than 40 million molecules were generated. Compounds which comply with Ro5 criteria were selected. Inappropriate chemical structures, such as PAINS motifs and synthetically difficult accessible, were removed. Based on Morgan Fingerprint, molecular clustering analysis was carried out, and molecules close to each clustering center were extracted to form this drug-like and synthesizable diversity library. These selected molecules have 805,822 unique Bemis-Murcko Scaffolds (BMS) with diversified chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113066A

Guanosine 5'-diphosphate disodium salt 2 Publications Verification GDP disodium salt	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (GDP) disodium salt is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate disodium salt can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-111134

TAN 420C	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields Other Antibiotics Cancer	Antibiotic
TAN 420C is an antibiotic that shows a strong cytotoxic activity against the lymphocytic leukemia .

HY-113066

Guanosine 5'-diphosphate GDP	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-113066C

Guanosine 5'-diphosphate sodium GDP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate sodium is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-N7569

Demethoxyfumitremorgin C	Structural Classification Alkaloids Microorganisms Source classification Marine natural products Other marine organisms Indole Alkaloids	Apoptosis Caspase PPAR
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to **PARP/ cleavage .**

HY-156043

4,5-Dihydroxy-2,3-pentanedione	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4,5-Dihydroxy-2,3-pentanedione is a production of S-ribosylhomocysteine. 4,5-Dihydroxy-2,3-pentanedione reacts with boric acid to synthesize AI-2 (an autoinducer) .

HY-P2569

Malformin A1	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .

HY-N10481

Aviculin	Classification of Application Fields Polygonum aviculare L. Polygonaceae Source classification Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis Caspase PARP Bcl-2 Family
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC₅₀ of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio .

HY-N0135

Tanshinone IIA 10+ Cited Publications Dan Shen ketone	Quinones Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants Naphthalene Quinones Disease Research Fields Cancer	VEGFR
Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

HY-N6818

5,7,4'-Trimethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Cancer Zingiberaceae	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase *(PARP)* protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-113432

Nudifloramide 2PY	Alkaloids Structural Classification Classification of Application Fields Other disease Source classification Disease markers Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite PARP
Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .

HY-N1094

Verminoside	other families Iridoids Classification of Application Fields Anti-aging Terpenoids Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	PARP MDM-2/p53
Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of *PARP-1* and p53 proteins .

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

HY-N1988

Cucurbitacin IIa Hemslecin A	Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Plants Hemsleya chinensis Cogn. ex Forbes et Hemsl. Disease Research Fields Cancer	Survivin Apoptosis
Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells .

HY-122935

Nigranoic acid	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	HIV Reverse Transcriptase
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-N6861

Lucidenic acid B	Triterpenes Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells .

HY-N3584

Paris saponin VII 1 Publications Verification Chonglou Saponin VII	Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of *Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt*. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N3825

ent-Kaurane-3α,16β,17-triol	Structural Classification Terpenoids Source classification Euphorbia stracheyi Boiss. Diterpenoids Euphorbiaceae Plants	Apoptosis
ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells .

HY-Z0283

Benzamide Benzenecarboxamide; Phenylamide	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite PARP
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-N0674A

Dehydrocorydaline chloride Maximum Cited Publications 22 Publications Verification 13-Methylpalmatine chloride	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates *PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0674

Dehydrocorydaline Maximum Cited Publications 22 Publications Verification 13-Methylpalmatine	Infection Alkaloids Structural Classification Classification of Application Fields Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates *PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0674B

Dehydrocorydaline (hydroxyl) 20+ Cited Publications 13-Methylpalmatine (hydroxyl)	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N4238

Dehydrocorydaline nitrate 20+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates *PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N8572

3',4'-Dimethoxyflavone	Flavonoids other families Flavones Coniogramme japonica (Thunb.) Diels Plants	PARP Reactive Oxygen Species Aryl Hydrocarbon Receptor
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of *PARP* and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

HY-123033A

Nicotinamide riboside chloride 5+ Cited Publications	Alkaloids Structural Classification Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Pyridine Alkaloids Metabolic Disease Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside Chloride, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033

Nicotinamide riboside	Natural Products Human Gut Microbiota Metabolites Microorganisms Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033B

Nicotinamide riboside tartrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside tartrate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033C

Nicotinamide riboside malate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside malate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

Species:	Human (27) Virus (3) Mouse (4) E.coli (1) Cynomolgus (1)
Tag:	His (25) SUMO (1) Tag Free (3) Strep (1) Avi (8) GST (3) Fc (6) Flag (1)
Source:	HEK293 (20) Sf9 insect cells (1) Sf9 insect cells (3) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P74652

	PARP Protein, Human (sf9, His) ADPRT 1; ADPRT; parp apoptosis; parp; PPOL	Human	Sf9 insect cells
	The PARP1 protein is a polyADP-ribosyltransferase that crucially mediates polyADP-ribosylation (PARsylation) in DNA repair, including base excision and double-strand breaks. By interacting with factors such as HPF1 and NMNAT1, the specificity of PARP1 extends to various amino acids. PARP Protein, Human (sf9, His) is the recombinant human-derived PARP protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of PARP Protein, Human (sf9, His) is 1014 a.a., with molecular weight of 100-110 kDa.

HY-P73337

	PARP Protein, Mouse (sf9, His) ADPRT 1; ADPRT; parp apoptosis; parp; PPOL	Mouse	Sf9 insect cells
	PARP, a poly-ADP-ribosyltransferase, catalyzes poly-ADP-ribosylation, crucial for DNA repair. This protein irreversibly binds to DNA breaks, disrupting repair processes and triggering DNA damage-induced apoptosis. PARP Protein, Mouse (sf9, His) is the recombinant mouse-derived PARP protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PARP Protein, Mouse (sf9, His) is 1014 a.a., with molecular weight of ~75 kDa.

HY-P7526

	Apolipoprotein A-I/APOA1 Protein, Human rHuApolipoprotein A-I; ApoA1; Apolipoprotein A-I	Human	E. coli
	Apolipoprotein A-I Protein, Human expresses in E. coli. Apolipoprotein A-I (ApoA-I), the major protein component in high-density lipoprotein (HDL), plays key roles in the Reverse Cholesterol Transport pathway. Apolipoprotein A-I is associated with dengue virus (DV) particles and enhances virus infection through SR-BI.

HY-P75955

	PARP3 Protein, Human (sf9, His-GST) Protein mono-ADP-ribosyltransferase parp3; ARTD3; IRT1; ADPRT-3; parp-3	Human	Sf9 insect cells
	The PARP3 protein is a mono-ADP ribosyltransferase that responds to DNA damage, focusing on mono-ADP ribosylation of proteins such as histone H2B, XRCC5, and XRCC6. PARP3 plays a key role in the DNA repair process, participating in precise nonhomologous end joining and inhibiting G-quadruplex structure. PARP3 Protein, Human (sf9, His-GST) is the recombinant human-derived PARP3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PARP3 Protein, Human (sf9, His-GST) is 533 a.a., with molecular weight of ~95 kDa.

HY-P701954

	PARP6 Protein, Human parp6; Protein mono-ADP-ribosyltransferase parp6; ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; Poly [ADP-ribose] polymerase 6; parp-6	Human	E. coli
	PARP6 protein, a mono-ADP-ribosyltransferase, specializes in mediating the mono-ADP-ribosylation of target proteins. PARP6 Protein, Human is the recombinant human-derived PARP6 protein, expressed by E. coli , with tag free. The total length of PARP6 Protein, Human is 227 a.a., .

HY-P7525

	Apolipoprotein A-I/APOA1 Protein, Human (HEK293, His) 1 Publications Verification rHuApolipoprotein A-I, His; ApoA1; Apolipoprotein A-I	Human	HEK293
	Apolipoprotein A-I Protein, Human (HEK293, His) expresses in HEK293 with a His tag at the N-terminus. Apolipoprotein A-I (ApoA-I), the major protein component in high-density lipoprotein (HDL), plays key roles in the Reverse Cholesterol Transport pathway. Apolipoprotein A-I is associated with dengue virus (DV) particles and enhances virus infection through SR-BI.

HY-P72832

	Apolipoprotein A-I/APOA1 Protein, Human (HEK293, Fc) Apolipoprotein A-I; Apo-Ai; ProapoA-I; APOA1	Human	HEK293
	Apolipoprotein AI plays a key role in reverse cholesterol transport, promoting cholesterol efflux from tissues and acting as a cofactor for lecithin cholesterol acyltransferase (LCAT). It forms homodimers and participates in the SPAP complex, which is essential for sperm motility, interacting with both NAXE and CLU. Apolipoprotein A-I/APOA1 Protein, Human (HEK293, Fc) is the recombinant human-derived Apolipoprotein A-I/APOA1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Apolipoprotein A-I/APOA1 Protein, Human (HEK293, Fc) is 243 a.a., with molecular weight of 55-65 kDa.

HY-P701955

	PARP6 Protein, Human (FLAG, GST, Avi) parp6; Protein mono-ADP-ribosyltransferase parp6; ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; Poly [ADP-ribose] polymerase 6; parp-6	Human	E. coli
	PARP6 protein, a mono-ADP-ribosyltransferase, specializes in mediating the mono-ADP-ribosylation of target proteins. PARP6 Protein, Human (FLAG, GST, Avi) is the recombinant human-derived PARP6 protein, expressed by E. coli , with C-Avi, N-Flag, N-GST labeled tag. The total length of PARP6 Protein, Human (FLAG, GST, Avi) is 227 a.a., .

HY-P701951

	PARP14 Protein, Human parp14; Protein mono-ADP-ribosyltransferase parp14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2; Poly [ADP-ribose] polymerase 14; parp-14	Human	E. coli
	The PARP14 protein is an ADP-ribosyltransferase that uniquely mono-ADP-ribosylates glutamic acid residues on target proteins such as STAT1 and STAT6, unlike PARP1 and PARP2. It catalyzes STAT1 mono-ADP ribosylation at “Glu-657” and “Glu-705”, reduces STAT1 phosphorylation and inhibits the production of pro-inflammatory cytokines in macrophages following IFNG stimulation. PARP14 Protein, Human is the recombinant human-derived PARP14 protein, expressed by E. coli , with tag free. The total length of PARP14 Protein, Human is 180 a.a., .

HY-P72833

	Apolipoprotein A-I/APOA1 Protein, Mouse (246a.a, HEK293, Fc) Apolipoprotein A-I; Apo-Ai; ProapoA-I; APOA1	Mouse	HEK293
	The apolipoprotein AI (APOA1) protein is key to reverse cholesterol transport, promoting tissue efflux, and serves as an important cofactor for lecithin cholesterol acyltransferase (LCAT), promoting cholesterol excretion. As a homodimer, APOA1 is a component of the sperm activating protein complex (SPAP), interacts with APOA1BP, CLU, NDRG1, SCGB3A2, NAXE and YJEFN3, exhibiting multiple molecular associations. Apolipoprotein A-I/APOA1 Protein, Mouse (246a.a, HEK293, Fc) is the recombinant mouse-derived Apolipoprotein A-I/APOA1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Apolipoprotein A-I/APOA1 Protein, Mouse (246a.a, HEK293, Fc) is 246 a.a., with molecular weight of ~58 kDa.

HY-P701952

	PARP14 Protein, Human (His, Strep) parp14; Protein mono-ADP-ribosyltransferase parp14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2; Poly [ADP-ribose] polymerase 14; parp-14	Human	E. coli
	The PARP14 protein is an ADP-ribosyltransferase that uniquely mono-ADP-ribosylates glutamic acid residues on target proteins such as STAT1 and STAT6, unlike PARP1 and PARP2. It catalyzes STAT1 mono-ADP ribosylation at “Glu-657” and “Glu-705”, reduces STAT1 phosphorylation and inhibits the production of pro-inflammatory cytokines in macrophages following IFNG stimulation. PARP14 Protein, Human (His, Strep) is the recombinant human-derived PARP14 protein, expressed by E. coli , with N-Strep, N-8*His labeled tag. The total length of PARP14 Protein, Human (His, Strep) is 180 a.a., .

HY-P701953

	PARP15 Protein, Human (His) parp15; Protein mono-ADP-ribosyltransferase parp15; ADP-ribosyltransferase diphtheria toxin-like 7; ARTD7; B-aggressive lymphoma protein 3; Poly [ADP-ribose] polymerase 15; parp-15	Human	E. coli
	PARP15 protein, acting as a mono-ADP-ribosyltransferase, facilitates the mono-ADP-ribosylation of target proteins. It also functions as a transcriptional negative regulator, impacting cellular processes and gene expression. PARP15 Protein, Human (His) is the recombinant human-derived PARP15 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PARP15 Protein, Human (His) is 176 a.a., .

HY-P76005

RVFV-L Protein (His)

Rift Valley fever virus (tan/Dod-002/07) RVFV-L Protein (His)
Virus E. coli

HY-P78004

	MARCO Protein, Human (HEK293, His) MARCO; SCARA2; Ai323439; Ly112	Human	HEK293
	MARCO Protein, a pattern recognition receptor (PRR), binds both Gram-positive and Gram-negative bacteria, facilitating unopsonized particle binding by alveolar macrophages. It also interacts with the secretoglobin SCGB3A2. Forming disulfide-linked homotrimer structures, MARCO Protein's trimers assemble into larger oligomers, providing an expansive surface area for interactions with substantial ligands. MARCO Protein, Human (HEK293, His) is the recombinant human-derived MARCO protein, expressed by HEK293 , with N-His labeled tag. The total length of MARCO Protein, Human (HEK293, His) is 116 a.a., with molecular weight of 14-20 kDa.

HY-P78501

	NOTCH1 Protein, Human (HEK293, His-Avi) Notch-1; tan1; NOTCH1; 9930111A19Rik; lin-12; Mis6; N1	Human	HEK293
	NOTCH1 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and is critical for cell fate decisions. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes in the cleavage site enhancer. NOTCH1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived NOTCH1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of NOTCH1 Protein, Human (HEK293, His-Avi) is 508 a.a., with molecular weight of 70-80 kDa.

HY-P78238

	Apolipoprotein A-I/APOA1 Protein, Mouse (240a.a, HEK293, Fc) Apo-Ai; ProapoA-I; Apoa1; Apolipoprotein A-I; APOA1; MGC117399; Alp-1; Brp-14; Ltw-1; Lvtw-1; Sep-1; Sep-2	Mouse	HEK293
	Apolipoprotein A-I (APOA1) Protein, pivotal in cholesterol reverse transport, facilitates efflux from tissues and acts as a crucial cofactor for lecithin cholesterol acyltransferase (LCAT), promoting cholesterol excretion. As a homodimer, APOA1 is integral to the sperm activating protein complex (SPAP), interacting with APOA1BP, CLU, NDRG1, SCGB3A2, NAXE, and YJEFN3, demonstrating diverse molecular associations. Its involvement extends beyond cholesterol metabolism to influence cellular processes like spermatozoa motility and protein interactions. Apolipoprotein A-I/APOA1 Protein, Mouse (240a.a, HEK293, Fc) is the recombinant mouse-derived Apolipoprotein A-I/APOA1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of Apolipoprotein A-I/APOA1 Protein, Mouse (240a.a, HEK293, Fc) is 240 a.a., with molecular weight of 55-65 kDa.

HY-P78184

	NOTCH1 Protein, Human (Biotinylated, HEK293, His-Avi) Notch-1; tan1; NOTCH1; 9930111A19Rik; lin-12; Mis6; N1	Human	HEK293
	NOTCH1 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and is critical for cell fate decisions. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes in the cleavage site enhancer. NOTCH1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived NOTCH1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of NOTCH1 Protein, Human (Biotinylated, HEK293, His-Avi) is 508 a.a., with molecular weight of 70-80 kDa.

HY-P77835

	SFRP2 Protein, Human (HEK293, His, solution) sFRP-2; SARP-1; Sarp1; Sdf5; Sfrp2; Ai851596	Human	HEK293
	SFRP2 Protein is a soluble crimson-associated protein that promotes tumor development by activating the Wnt/β-catenin signaling pathway. The methylation of SFRP2 Protein DNA is associated with tumor development. SFRP2 Protein, Human (HEK293, His, solution) is the recombinant human-derived SFRP2 protein, expressed by HEK293 , with C-His labeled tag. The total length of SFRP2 Protein, Human (HEK293, His, solution) is 271 a.a., with molecular weight of 34-38 kDa.

HY-P78487

	CD229/SLAMF3 Protein, Human (HEK293, His-Avi) SLAMF3; CD229; LY9; Ai893573; Lgp100; T100	Human	HEK293
	The CD229/SLAMF3 protein is an autoligand receptor in the SLAM family that regulates immune cell activation and differentiation through cell interactions. Essential for innate and adaptive immune responses, its activity is controlled by SH2D1A/SAP and/or SH2D1B/EAT-2. CD229/SLAMF3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD229/SLAMF3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD229/SLAMF3 Protein, Human (HEK293, His-Avi) is 407 a.a., with molecular weight of 70-80 kDa.

HY-P76155

	APOA1BP Protein, Human (HEK293, His) NAD(P)H-hydrate epimerase; Apolipoprotein A-I-binding protein; Ai-BP; YJEFN1; NAXE; AiBP	Human	HEK293
	APOA1BP protein plays a crucial role in cellular processes by catalyzing the S- and R-type epimerization of NAD(P)HX, a protein that results from enzymatic or heat-dependent hydration. Damaged form of NAD(P)H. This catalytic activity is a prerequisite for the subsequent action of S-specific NAD(P)H hydrate dehydratase, enabling the repair of both epimers of NAD(P)HX. APOA1BP Protein, Human (HEK293, His) is the recombinant human-derived APOA1BP protein, expressed by HEK293 , with C-His labeled tag. The total length of APOA1BP Protein, Human (HEK293, His) is 288 a.a., with molecular weight of ~30.6 KDa.

HY-P700672

	CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi) SLAMF3; CD229; LY9; Ai893573; Lgp100; T100	Human	HEK293
	CD229/SLAMF3 Protein, a self-ligand receptor in the SLAM family, modulates immune cell activation and differentiation through cell interactions. Crucial for innate and adaptive immune responses, its activities are controlled by SH2D1A/SAP and/or SH2D1B/EAT-2. It mediates T-cell adhesion, promotes Th17 differentiation with IL-17 secretion requiring SH2D1A, and facilitates RORC recruitment to the IL-17 promoter. CD229/SLAMF3 acts as a negative immune regulator, inhibiting autoantibody responses and CD4(+) T-cell IFN-gamma secretion. It regulates thymic innate CD8(+) T-cell size and iNKT cell development, interacting with SH2D1A, SH2D1B, INPP5D, and PTPN11, blocking PTPN11 interaction with SH2D1A. CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD229/SLAMF3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi) is 407 a.a., with molecular weight of 70-80 kDa.

HY-P72118

	CBS Protein, Human (His) Ai047524; Ai303044; Beta thionase; Beta-thionase; Cbs; Cbs cystathionine beta-synthase; CBS_HUMAN; Cystathionine beta synthase; Cystathionine beta-synthase; EC 4.2.1.22; HIP 4; HIP4; Methylcysteine synthase; MGC18856; MGC18895; MGC37300; OTTHUMP00000109416; OTTHUMP00000109418; Serine sulfhydrase	Human	E. coli
	CBS, a hydro-lyase, initiates the transsulfuration pathway by catalyzing the beta-replacement reaction, converting L-serine to L-cystathionine using L-homocysteine. This process eliminates L-methionine and the potentially harmful metabolite L-homocysteine. CBS, beyond its catabolic role, contributes to hydrogen sulfide production, serving as a gasotransmitter with signaling and cytoprotective effects, particularly on neurons. CBS Protein, Human (His) is the recombinant human-derived CBS protein, expressed by E. coli , with N-6*His labeled tag. The total length of CBS Protein, Human (His) is 550 a.a., with molecular weight of ~64.5 kDa.

HY-P71627

	AMELX Protein, Human (His-SUMO) Ai1E; AiH1; ALGN; Amel; Amelogenesis imperfecta 1; Amelogenin (amelogenesis imperfecta 1; X isoform	Human	E. coli
	AMELX Protein plays a central role in biomineralization, shaping crystallite formation during the secretory stage of tooth enamel development. Its pivotal function extends to structurally organizing and mineralizing developing enamel, emphasizing its significance in dental tissue architecture. Interactions with KRT5 suggest its involvement in molecular networks contributing to the orchestrated development and mineralization of tooth enamel. AMELX Protein, Human (His-SUMO) is the recombinant human-derived AMELX protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of AMELX Protein, Human (His-SUMO) is 175 a.a., with molecular weight of ~35.9 kDa.

HY-P702585

	PARP2 Protein, Human (sf9, His) Poly [ADP-ribose] polymerase 2; ADP-ribosyltransferase diphtheria toxin-like 2; DNA ADP-ribosyltransferase parp2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; pADPRT-2; EC:2.4.2.30; ADPRT2; ADPRTL2	Human	Sf9 insect cells

HY-P75414

	CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc) Ai504783 Protein; CD3 Protein; CD3epsilon Protein; T3e Protein	Mouse	HEK293
	The CD3E protein, with predicted functions like SH3 domain binding and protein heterodimerization, plays a crucial role in nervous system development and cell adhesion. It is involved in T cell activation, cytokine production, and signal transduction. Located in various cellular components, its expression is observed in the colon and hemolymphoid system. CD3E, the human ortholog, has implications in immunodeficiency 18, emphasizing its role in immune system functionality. Biased expression occurs in the thymus and spleen, highlighting its importance in immune processes. CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc) is a recombinant protein dimer complex containing mouse-derived CD3E-CD3G Heterodimer protein, expressed by HEK293, with C-hFc labeled tag. CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc), has molecular weight of ~38-40 kDa.

HY-P77875

	AXL Protein, Human (HEK293, Fc) Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; Ai323647; EC 2.7.10; EC 2.7.10.1	Human	HEK293
	AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (HEK293, Fc) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AXL Protein, Human (HEK293, Fc) is 424 a.a., with molecular weight of 80-110 kDa.

HY-P71528

	LUXS Protein, E.coli (His) luxS; ygaG; b2687; JW2662; S-ribosylhomocysteine lyase; EC 4.4.1.21; Ai-2 synthesis protein; Autoinducer-2 production protein LuxS	E.coli	E. coli
	LUXS proteins are critical for the synthesis of bacterially secreted autoinducer 2 (AI-2), which promotes communication between cell density and environmental metabolism. LUXS is critical for quorum sensing and catalyzes S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentanedione (DPD) , revealing its enzymatic role in AI-2 production. LUXS Protein, E.coli (His) is the recombinant E. coli-derived LUXS protein, expressed by E. coli , with N-6*His labeled tag. The total length of LUXS Protein, E.coli (His) is 170 a.a., with molecular weight of 23-25 kDa.

HY-P77876

	AXL Protein, Human (Biotinylated, HEK293, Fc) Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; Ai323647; EC 2.7.10; EC 2.7.10.1	Human	HEK293
	AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (Biotinylated, HEK293, Fc) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AXL Protein, Human (Biotinylated, HEK293, Fc) is 424 a.a., with molecular weight of 80-110 kDa.

HY-P77877

	AXL Protein, Human (HEK293, His-Avi) Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; Ai323647; EC 2.7.10; EC 2.7.10.1	Human	HEK293
	AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (HEK293, His-Avi) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of AXL Protein, Human (HEK293, His-Avi) is 424 a.a., with molecular weight of 70-80 kDa.

HY-P77878

	AXL Protein, Human (Biotinylated, HEK293, His-Avi) Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; Ai323647; EC 2.7.10; EC 2.7.10.1	Human	HEK293
	AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of AXL Protein, Human (Biotinylated, HEK293, His-Avi) is 424 a.a., with molecular weight of 70-80 kDa.

HY-P77567

	AXL Protein, Cynomolgus (417a.a, HEK293, His) Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; Ai323647; EC 2.7.10; EC 2.7.10.1	Cynomolgus	HEK293
	AXL Protein, a receptor tyrosine kinase, mediates signals by binding GAS6, regulating cell survival, proliferation, migration, and differentiation. Upon ligand binding, AXL undergoes dimerization and autophosphorylation, activating downstream molecules like PI3-kinase subunits, GRB2, PLCG1, and more. This triggers AKT kinase activation, influencing processes such as endothelial cell survival, cytokine signaling in NK cell development, hepatic regeneration, gonadotropin-releasing hormone neuron function, platelet activation, thrombotic responses, and immune modulation. AXL also serves as a receptor for lassa virus and lymphocytic choriomeningitis virus during microbial infection. AXL Protein, Cynomolgus (417a.a, HEK293, His) is the recombinant cynomolgus-derived AXL protein, expressed by HEK293 , with C-His labeled tag. The total length of AXL Protein, Cynomolgus (417a.a, HEK293, His) is 417 a.a., with molecular weight of 68-70 kDa.

HY-P74946

	HA1/Hemagglutinin Protein, H5N2 (ABQ24010, HEK293, His) Influenza A H5N2 (A/ostrich/South Africa/Ai1091/2006) Hemagglutinin Protein (HA1 Subunit) (His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways. As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane. HA1/Hemagglutinin Protein, H5N2 (ABQ24010, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag. The total length of HA1/Hemagglutinin Protein, H5N2 (ABQ24010, HEK293, His) is 355 a.a., with molecular weight of ~50 kDa.

HY-P74982

	HA1/Hemagglutinin Protein, H1N8 (ACT83229, HEK293, His) Influenza A H1N8 (A/Egyptian goose/South Africa/Ai1448/2007) Hemagglutinin / HA1 Protein (His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways. As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane. HA1/Hemagglutinin Protein, H1N8 (ACT83229, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag. The total length of HA1/Hemagglutinin Protein, H1N8 (ACT83229, HEK293, His) is 344 a.a., with molecular weight of ~37.6 kDa.

HY-P78163

	IL-13R alpha 1 Protein, Human (Biotinylated, HEK293, His-Avi) IL-13 R alpha 1; IL13R; IL13RA; CT19; IL13RA1; NR4; CD213A1; Ai882074	Human	HEK293
	The IL13RA1 protein is critical in immune signaling and binds with low affinity to IL13. It binds to IL4RA to form a functional IL13 receptor for cellular responses. IL-13R alpha 1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of IL-13R alpha 1 Protein, Human (Biotinylated, HEK293, His-Avi) is 317 a.a., with molecular weight of 55-75 kDa.

HY-P72119

	CCND1 Protein, Human (His) Ai327039; B cell leukemia 1; B-cell lymphoma 1 protein; BCL 1; BCL-1; BCL-1 oncogene; BCL1; BCL1 oncogene; ccnd1; CCND1/FSTL3 fusion gene; CCND1/FSTL3 fusion gene; included; CCND1/IGHG1 fusion gene; CCND1/IGLC1 fusion gene; CCND1_HUMAN; cD1; Cyl 1; D11S287E; G1/S specific cyclin D1; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31	Human	E. coli
	The CCND1 protein is a regulatory component of the cyclin D1-CDK4 complex that coordinates phosphorylation and RB family inhibition to regulate the G(1)/S transition. This promotes the dissociation of E2F from the RB/E2F complex and promotes the transcription of E2F target genes critical for G(1) phase progression. CCND1 Protein, Human (His) is the recombinant human-derived CCND1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CCND1 Protein, Human (His) is 295 a.a., with molecular weight of ~37.7 kDa.

HY-P71534

	DDX39B Protein, Human (GST) 0610030D10Rik; 4F2-LC6; 56kDa U2AF65-associated protein; Ai428441; ATP-dependent RNA helicase p47; B(0,+)-type amino acid transporter 1; BAT1; Bat1a; D17H6S81E; D17H6S81E-1; D6S81E; D6S81Eh; DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; DX39B_HUMAN; EC 3.6.1.-; Glycoprotein-associated amino acid transporter b0,+AT1; HLA-B-associated transcript 1 protein; HLA-B-associated transcript 1A; HLA-B-associated transcript-1; MGC127051; MGC19235; MGC38799; nuclear RNA helicase (DEAD family); OTTHUMP00000029229; OTTHUMP00000165889; OTTHUMP00000165890; p47; Solute carrier family 7 member 9; Spliceosome RNA helicase BAT1; Spliceosome RNA helicase DDX39B; U2AF65-associayed protein; 56-KD; UAP56	Human	E. coli
	The DDX39B protein intricately coordinates nuclear mRNA export and is specifically associated with spliced mRNA as a key component of the TREX complex. This coupling of mRNA transcription, processing, and export involves rounds of ATP-dependent hydrolysis, recruiting components such as ALYREF/THOC and CHTOP. DDX39B Protein, Human (GST) is the recombinant human-derived DDX39B protein, expressed by E. coli , with N-GST labeled tag. The total length of DDX39B Protein, Human (GST) is 250 a.a., with molecular weight of ~55.2 kDa.

Cat. No.	Product Name	Chemical Structure

HY-10162S

Olaparib-d5

Olaparib-d₅ is a deuterium labeled Olaparib. Olaparib is a potent and oral PARP inhibitor[1].

HY-113066S2

Guanosine 5'-diphosphate-d13 dilithium

Guanosine 5'-diphosphate-d₁₃ (GDP-d₁₃) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S1

Guanosine 5'-diphosphate-13C10 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀ (GDP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S

Guanosine 5'-diphosphate-15N5 dilithium

Guanosine 5'-diphosphate- ¹⁵N₅ (GDP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S3

Guanosine 5'-diphosphate-13C10,15N5 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀, ¹⁵N₅ (GDP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-Z0283S

Benzamide-15N

Benzamide- ¹⁵N is a ¹⁵N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP)[1][2].

HY-10162S1

Olaparib-d8
Olaparib-d₈ is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

HY-10162S3

Olaparib-d4-1
Olaparib-d₄-1 is the deuterium labeled Olaparib. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

HY-16106S

Talazoparib-13C,d4
Talazoparib- ¹³C,d4 is ¹³C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.

HY-113432S

Nudifloramide-d3
Nudifloramide-d₃ (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].

HY-A0067S

Oxybenzone-d5

Oxybenzone-d₅ is the deuterium labeled Oxybenzone[1]. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells[2][3][4].

Cat. No.	Product Name	Application	Reactivity

HY-P80263

PARP1 Antibody parp-1; ARTD1; ADPRT 1; parp1	WB, ICC/IF, IHC-P, FC	Human, Mouse
PARP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 113 kDa, targeting to PARP. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80596

CD147 Antibody HT-7; CD147; EMMPRIN; Ai115436; Ai325119	WB, IHC-P, FC, IP	Human, Mouse
CD147 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 42 kDa, targeting to CD147. It can be used for WB,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse.

HY-P80265

PARP2 Antibody	WB, FC	Human
PARP2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 66 kDa, targeting to PARP2. It can be used for WB,FC assays with tag free, in the background of Human.

HY-P80448

*Cleaved PARP* Antibody**	WB, ICC, IP, FC	Human
Cleaved PARP Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 89 kDa, targeting to Cleaved PARP. It can be used for WB,ICC,IP,FC assays with tag free, in the background of Human.

HY-P81899

PIP5K1C Antibody (YA1644)

Ai115456; Ai835305; Pip5kIgamma
WB, IP Human, Mouse

HY-P80768

Notch1 Antibody NOTCH1; tan1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein tan-1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
Notch1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 273 kDa, targeting to Notch1. It can be used for WB,IHC-P,ICC/IF,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P83122

DLX3 Antibody (YA2867)

Ai4; TDO
WB Human
HY-P83541

N4BP1 Antibody (YA3286)

C81621; Ai481586
WB, IP Human
HY-P82362

Pulmonary Surfactant Associated Protein D Antibody (YA2107)

SP-D; Sfpd; Sftp4; Ai573415
WB, IHC-P Rat

HY-P80625

*Cleaved-PARP1 Antibody* parp1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; parp-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1	WB	Human
Cleaved-PARP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 113 kDa, targeting to Cleaved-PARP1. It can be used for WB assays with tag free, in the background of Human.

HY-P80780

PARP1 Antibody (YA245) parp1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; parp-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
PARP1 Antibody (YA245) is a non-conjugated and Rabbit origined monoclonal antibody about 113 kDa, targeting to PARP1. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P83377

Integrin beta 6 Antibody (YA3122)

Ai1H; Integrin beta-6
WB, IP Human, Mouse, Rat

HY-P81137

APOA1 Antibody Apo-Ai; ApoA I; ApoA-I; APOA1_HUMAN; Apolipoprotein A-I(1-242); Apolipoprotein A1; Apolipoprotein A 1; Apolipoprotein Ai; Apolipoprotein A I; Brp14; Ltw1; Lvtw1; Sep1; Sep2.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat, Chicken(predicted: Pig, Cow)
APOA1 Antibody is an unconjugated, approximately 28 kDa, rabbit-derived, anti-APOA1 polyclonal antibody. APOA1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, chicken, and predicted: pig, cow background without labeling.

HY-P80589

Caspase 7 Antibody Mch3; CMH-1; mCASP-7; Ai314680; ICE-IAP3; caspase-7	WB, ICC/IF, IP	Mouse, Rat
Caspase 7 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Caspase 7. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Mouse, Rat.

HY-P80653

eIF5A Antibody EIF-5A; EIF5A1; eIF5Ai; Eukaryotic initiation factor 5A	WB, IHC-P, IP	Human, Mouse, Rat
eIF5A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 17 kDa, targeting to eIF5A. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81881

Phospholipase C beta 1 Antibody (YA1626)

Plcb; Ai132408; mKIAA0581; 3110043I21Rik
WB Rat
HY-P82780

Clusterin alpha Chain Antibody (YA2525)

Cli; ApoJ; Sgp2; SP-40; Sgp-2; Sugp-2; Ai893575; D14Ucla3
WB, IP Rat

HY-P80979

HOPX Antibody Hod; Hop; Ob1; Obl; Hdop; Toto; Cameo; Ai848177; AW490897; 1110018K11Rik; 1200015P04Rik; 2300002F06Rik	WB, IP	Human
HOPX Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 8 kDa, targeting to HOPX. It can be used for WB, IP assays with tag free, in the background of Human.

HY-P83587

Hydroxyl-Histone H2A Antibody (YA3332) H2A.1; H2A/c; H2A1; H2AFC:; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2Ai; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone cluster 1; H2Ai; Histone H2A type 1; Histone H2A/p	WB, IHC-P	Human, Mouse

HY-P81138

CD166 Antibody activated leukocyte cell adhesion molecule; ALCAM protein; ALCAM; CD 166; CD166 antigen; FLJ38514; MEMD; MGC71733; FLJ3851; Ai853494; BEN; DM-GRASP; MGC27910; MuSC; SC1; CD166_HUMAN.	WB; ELISA; IHC-F; Flow-Cyt; IF	Human(predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit)
CD166 Antibody is an unconjugated, approximately 62 kDa, rabbit-derived, anti-CD166 polyclonal antibody. CD166 Antibody can be used for: WB, ELISA, IHC-F, Flow-Cyt, IF expriments in human, and predicted: mouse, rat, chicken, dog, pig, cow, horse, rabbit background without labeling.

HY-P81175

MyoD1/Myf3 Antibody Myogenic differentiation 1; Ai503393; bHLHc1; MD1; MGC156574; MYF3; MYOD; MYOD1; PUM; MYOD1_HUMAN; Class C basic helix-loop-helix protein 1; bHLHc1; Myogenic factor 3; Myf-3.	WB; ELISA	Mouse, Rat(predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep)
MyoD1/Myf3 Antibody is an unconjugated, approximately 35 kDa, rabbit-derived, anti-MyoD1/Myf3 polyclonal antibody. MyoD1/Myf3 Antibody can be used for: WB, ELISA expriments in mouse, rat, and predicted: human, chicken, dog, pig, cow, horse, rabbit, zebrafish, sheep background without labeling.

HY-P81198

AXL Antibody Adhesion related kinase; Ai323647; Ark; Axl; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming gene; AXL transforming sequence/gene; EC 2.7.10.1; JTK11; Oncogene AXL; Tyro7; Tyrosine protein kinase receptor UFO; Tyrosine-protein kinase receptor UFO; UFO; UFO_HUMAN.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse(predicted: Rat, Dog, Horse, Rabbit)
AXL Antibody is an unconjugated, approximately 95 kDa, rabbit-derived, anti-AXL polyclonal antibody. AXL Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat, dog, horse, rabbit background without labeling.

HY-P81478

NR2F2 Antibody (YA1223) NR2F2; ARP1; TFCOUP2; COUP transcription factor 2; COUP-TF2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2	IHC-P	Human

HY-P81082

Fbx32 Antibody (YA919) Fbx32; 4833442G10Rik; Ai430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein.	WB; ICC	Mouse, Rat(predicted: Human)
Fbx32 Antibody (YA919) is an unconjugated, approximately 42 kDa, rabbit-derived, anti-Fbx32 (YA919) monoclonal antibody. Fbx32 Antibody (YA919) can be used for: WB, ICC expriments in mouse, rat, and predicted: human background without labeling.

HY-P80728

JNK Antibody Ai849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8	WB, IP	Human, Mouse, Rat, Hamster
JNK Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to JNK. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P80729

JNK1 Antibody (YA720) Ai849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8	WB, ICC/IF	Human, Mouse, Rat
JNK1 (1A4) Antibody is a non-conjugated and Mouse origined monoclonal antibody about 48 kDa, targeting to JNK1 (1A4). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80831

Phospho-JNK1 (Thr183/Tyr185) Antibody Ai849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8	WB, IP	Human, Rat
Phospho-JNK1 (Thr183/Tyr185) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to Phospho-JNK1 (Thr183/Tyr185). It can be used for WB,IP assays with tag free, in the background of Human, Rat.

HY-P82975

Phospho-RPA2 (Thr21) Antibody (YA2720) 60S acidic ribosomal protein P1; AA409079; Ai325195; AU020965; HSSB; ik:tdsubc_2g1; M(2)21C; MGC137236; OTTHUMP00000004008; p32; p34; RCJMB04_6d17 replication protein A2; 32kDa; REPA 2; REPA1; REPA2; Replication factor A protein 2; Replication protein A 32 kDa subunit; Replication protein A 32kDa subunit; Replication protein A 34 kDa subunit; Replication protein A; replication protein A1 (70kD); Replication Protein A2 (32kDa); Replication protein A2 32kD; Replication protein A2 32kDa; Replication protein A2; Replication protein A2; 32kDa; RF A; RF-A protein 2; Rf-A2; RFA; RFA2_HUMAN; RP A; RP-A p32; RP-A p34; RP21C; RPA 2; RPA 32; RPA; RPA2; RPA32; RPA34; RPA70; RpLP1; RpP2; xx:tdsubc_2g1; zgc:109822.	WB, IP	Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-150221

DB008		Alkynes
DB008 is potent and selective *PARP16* inhibitor with an IC₅₀ value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively . DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130652

Pomalidomide 4'-PEG3-azide		Azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient *PARP1*?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-W021401

Amino-PEG3-C2-Azido		Azide PROTAC Synthesis
Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645) . Amino-PEG3-C2-Azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-145749

PARPYnD		Alkynes
PARPYnD is a *PARP* enzyme photoaffinity probe (AfBP) based on the triple *PARP1/2/6* inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC₅₀ of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells .

HY-130654

(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3		Azide
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM . (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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