PARP7-IN-12
PARP7-IN-12 is a potent PARP7 Inhibitor with an IC50 value of 7.836 nM. PARP7-IN-12 can be used in research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2819700-92-8
- Formula: C23H27ClF3N5O5
- Molecular Weight:545.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PARP7 7.836 nM (IC50) |
PARP7-IN-12 (compound 85A; 16-24 h) inhibits cell proliferative with an IC50 values of 20.722 nM in H1373 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice[1]
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Dosage:3 and 100 mg/kg
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Administration:Intravenous injection (3 mg/kg) and oral administration (10 mg/kg)
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Result:
1.19 Administration i.v. (3 mg/kg) p.o. (100 mg/kg) CL (mL/min/kg) 32 Vss (L/kg) 0.4 Cmax (ng/mL) 21733 AUClast (ng·h/mL) 26442 Oral BA (F%) 48
Chemical Information
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CAS No. 2819700-92-8
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Molecular Weight 545.94
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Formula C23H27ClF3N5O5
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SMILES
CC1=C2C(N3[C@@](CCO2)([H])CN(CC3)C(CCOC[C@H](C)OC4=C(C(NN=C4)=O)C(F)(F)F)=O)=NC=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP7-IN-12 Related Classifications
HY-151609 Related Classifications
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