PARP7-IN-12
PARP7-IN-12 is a potent PARP7 Inhibitor with an IC50 value of 7.836 nM. PARP7-IN-12 can be used in research of cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2819700-92-8
- Formel: C23H27ClF3N5O5
- Molecular Weight:545.94
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PARP7 7.836 nM (IC50) |
In Vitro
PARP7-IN-12 (compound 85A; 16-24 h) inhibits cell proliferative with an IC50 values of 20.722 nM in H1373 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice[1]
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Dosage:3 and 100 mg/kg
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Administration:Intravenous injection (3 mg/kg) and oral administration (10 mg/kg)
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Result:
1.19 Administration i.v. (3 mg/kg) p.o. (100 mg/kg) CL (mL/min/kg) 32 Vss (L/kg) 0.4 Cmax (ng/mL) 21733 AUClast (ng·h/mL) 26442 Oral BA (F%) 48
Chemical Information
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CAS. Nr. 2819700-92-8
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Molecular Weight 545.94
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Formel C23H27ClF3N5O5
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SMILES
CC1=C2C(N3[C@@](CCO2)([H])CN(CC3)C(CCOC[C@H](C)OC4=C(C(NN=C4)=O)C(F)(F)F)=O)=NC=C1Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PARP7-IN-12 Related Classifications
HY-151609 Related Classifications
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