2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. QTX125

QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (QTX125 TFA) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

QTX125 Chemical Structure

QTX125 Chemical Structure

CAS No. : 1279698-31-5

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QTX125 Related Antibodies

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1 Publications Citing Use of MCE QTX125

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

  • References

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Description

QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1].

IC50 & Target[1]

HDAC6

 

In Vitro

QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin[1].
QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QTX125 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours, 48 hours
Result: Inhibited annexin V/propidium iodide double staining.

Western Blot Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours
Result: Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.
In Vivo

QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing REC-1 or MINO cells[1]
Dosage: 60 mg/kg
Administration: Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result: Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
Molecular Weight

417.41

Formula

C23H19N3O5
CAS No.
SMILES

O=C(C1=C(C2=COC=C2)C=C(C3=CC=C(O)C=C3)N1)NCC4=CC=C(C(NO)=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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QTX125 Related Classifications

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QTX1251279698-31-5QTX 125QTX-125HDACApoptosisHistone deacetylasesα-tubulinHDAC6antitumorcaspase-9caspase-8caspase-3PARPInhibitorinhibitorinhibit

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