1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. HDAC
    Apoptosis
  3. QTX125

QTX125 

Cat. No.: HY-120448
Handling Instructions

QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.

For research use only. We do not sell to patients.

QTX125 Chemical Structure

QTX125 Chemical Structure

CAS No. : 1279698-31-5

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Description

QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1].

IC50 & Target[1]

HDAC6

 

In Vitro

QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin[1].
QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours, 48 hours
Result: Inhibited annexin V/propidium iodide double staining.

Western Blot Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours
Result: Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.
In Vivo

QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing REC-1 or MINO cells[1]
Dosage: 60 mg/kg
Administration: Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result: Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
Molecular Weight

417.41

Formula

C₂₃H₁₉N₃O₅

CAS No.
SMILES

O=C(C1=C(C2=COC=C2)C=C(C3=CC=C(O)C=C3)N1)NCC4=CC=C(C(NO)=O)C=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

QTX125QTX 125QTX-125HDACApoptosisHistone deacetylasesα-tubulinHDAC6antitumorcaspase-9caspase-8caspase-3PARPInhibitorinhibitorinhibit

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