In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma

  • Haematologica. 2018 Nov;103(11):e537-e540. doi: 10.3324/haematol.2018.189241.
Montserrat Pérez-Salvia  1 ,  Eneko Aldaba  2 ,  Yosu Vara  2 ,  Myriam Fabre  3 ,  Cristina Ferrer  3 ,  Carme Masdeu  4 ,  Aizpea Zubia  5 ,  Eider San Sebastian  5 ,  Dorleta Otaegui  6 ,  Pere Llinàs-Arias  1 ,  Margalida Rosselló-Tortella  1 ,  Maria Berdasco  1 ,  Catia Moutinho  1 ,  Fernando Setien  1 ,  Alberto Villanueva  7 ,  Eva González-Barca  8 ,  Josep Muncunill  9 ,  José-Tomás Navarro  9 ,  Miguel A Piris  10 ,  Fernando P Cossio  5 ,  Manel Esteller  11  12  13  14
Affiliations
  • 1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL) L'Hospitalet, Barcelona, Catalonia.
  • 2. Quimatryx, San Sebastian.
  • 3. Oncomatryx, Arteaga Auzoa, 43, Derio.
  • 4. Department of Organic Chemistry I, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), San Sebastián.
  • 5. Department of Organic Chemistry I, Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Donostia International Physics Center (DIPC), San Sebastián.
  • 6. Mass Spectrometry Platform, CIC biomaGUNE, San Sebastian.
  • 7. Laboratory of Translational Research, Catalan Institute of Oncology (ICO), IDIBELL L'Hospitalet, Barcelona, Catalonia.
  • 8. Department of Hematology, ICO-Hospital Duran i Reynals, IDIBELL, University of Barcelona, L'Hospitalet, Barcelona, Catalonia.
  • 9. Department of Hematology, ICO-Hospital Universitari Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Universitat Autònoma de Barcelona, Badalona, Catalonia.
  • 10. Pathology Service, Fundación Jiménez Díaz, Madrid.
  • 11. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL) L'Hospitalet, Barcelona, Catalonia [email protected].
  • 12. Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid.
  • 13. Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), L'Hospitalet, Catalonia.
  • 14. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.
PMID: 29880608 DOI: 10.3324/haematol.2018.189241
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