1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. HDAC
    Apoptosis
  3. QTX125 TFA

QTX125 TFA 

Cat. No.: HY-120448A
Handling Instructions

QTX125 TFA is a potent and highly selective HDAC6 inhibitor. QTX125 TFA exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.

For research use only. We do not sell to patients.

QTX125 TFA Chemical Structure

QTX125 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 Get quote
100 mg USD 2850 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of QTX125 TFA:

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Description

QTX125 TFA is a potent and highly selective HDAC6 inhibitor. QTX125 TFA exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1].

IC50 & Target[1]

HDAC6

 

In Vitro

QTX125 (25-500 nM; 24-48 hours) TFA treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 TFA (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin[1].
QTX125 TFA has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours, 48 hours
Result: Inhibited annexin V/propidium iodide double staining.

Western Blot Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours
Result: Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.
In Vivo

QTX125 TFA (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing REC-1 or MINO cells[1]
Dosage: 60 mg/kg
Administration: Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result: Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
Molecular Weight

531.44

Formula

C₂₅H₂₀F₃N₃O₇

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (235.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8817 mL 9.4084 mL 18.8168 mL
5 mM 0.3763 mL 1.8817 mL 3.7634 mL
10 mM 0.1882 mL 0.9408 mL 1.8817 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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QTX125 TFA
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HY-120448A
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