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Cat. No.: HY-162349

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PARP7/HDACs-IN-1

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

PARP7/HDACs-IN-1 (compound 9l) is a dual-target inhibitor targeting PARP7/HDAC with anti-tumor activity. PARP7/HDACs-IN-1 inhibits different subtypes of PARPs and HDACs with IC₅₀s of 83.3 nM (PARP1), 3.1 nM (PARP7), 35 nM (HDAC1), 30.3 nM (HDAC2), 35.4 nM (HDAC3), and 6.4 nM respectively. (HDAC6). br/.

For research use only. We do not sell to patients.

CAS No.: 3030144-11-4
Formula: C₂₉H₃₃F₃N₈O₆
Molecular Weight:646.62

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PARP7/HDACs-IN-1 Chemical Structure

CAS No.: 3030144-11-4

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target

IC50: 83.3 nM (PARP1), 3.1 nM (PARP7), 35 nM (HDAC1), 30.3 nM (HDAC2), 35.4 nM (HDAC3), 6.4 nM (HDAC6)^[1]

All HDAC Isoforms :

All PARP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	0.52 μM Compound: 9l	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay	[PMID: 38456618]
NCI-H1373	IC₅₀	0.31 μM Compound: 9l	Antiproliferative activity against human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by celltiter-glo luminescent assay Antiproliferative activity against human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by celltiter-glo luminescent assay	[PMID: 38456618]
U-937	IC₅₀	1.64 μM Compound: 9l	Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay	[PMID: 38456618]

Chemical Information

CAS No. 3030144-11-4
Molecular Weight 646.62
Formula C₂₉H₃₃F₃N₈O₆
SMILES

O=C1NN=CC(N[C@H](COCCC(N2CCN(CC2)C3=NC=C(C=N3)OCC4=CC=C(C=C4)/C=C/C(NO)=O)=O)C)=C1C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Duan J L, et al. Design, Synthesis, and Structure–Activity Relationship of Novel Pyridazinone-Based PARP7/HDACs Dual Inhibitors for Elucidating the Relationship between Antitumor Immunity and HDACs Inhibition[J]. Journal of Medicinal Chemistry, 2024.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

PARP7/HDACs-IN-1

1 Cited Publications

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Biological Activity
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Chemical Information
Publications (1)
Purity & Documentation
References

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PARP7/HDACs-IN-1

Publications Citing Use of MedChemExpress (MCE) PARP7/HDACs-IN-1

All HDAC Isoforms

All PARP Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

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Help & FAQs

PARP7/HDACs-IN-1 Related Classifications

HY-162349 Related Classifications