PARP7/HDACs-IN-1
Based on 1 publication(s) in Google Scholar
PARP7/HDACs-IN-1 (compound 9l) is a dual-target inhibitor targeting PARP7/HDAC with anti-tumor activity. PARP7/HDACs-IN-1 inhibits different subtypes of PARPs and HDACs with IC50s of 83.3 nM (PARP1), 3.1 nM (PARP7), 35 nM (HDAC1), 30.3 nM (HDAC2), 35.4 nM (HDAC3), and 6.4 nM respectively. (HDAC6). br/.
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- CAS 番号: 3030144-11-4
- 分子式: C29H33F3N8O6
- 分子量:646.62
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 PARP7/HDACs-IN-1
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生物活性
製品説明
IC50 & Target
IC50: 83.3 nM (PARP1), 3.1 nM (PARP7), 35 nM (HDAC1), 30.3 nM (HDAC2), 35.4 nM (HDAC3), 6.4 nM (HDAC6)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
0.52 μM
Compound: 9l
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay
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[PMID: 38456618] |
| NCI-H1373 | IC50 |
0.31 μM
Compound: 9l
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Antiproliferative activity against human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by celltiter-glo luminescent assay
Antiproliferative activity against human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by celltiter-glo luminescent assay
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[PMID: 38456618] |
| U-937 | IC50 |
1.64 μM
Compound: 9l
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Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay
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[PMID: 38456618] |
化学情報
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CAS 番号 3030144-11-4
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分子量 646.62
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分子式 C29H33F3N8O6
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SMILES
O=C1NN=CC(N[C@H](COCCC(N2CCN(CC2)C3=NC=C(C=N3)OCC4=CC=C(C=C4)/C=C/C(NO)=O)=O)C)=C1C(F)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PARP7/HDACs-IN-1 関連分類
HY-162349 関連分類
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