3030144-11-4
3030144-11-4
Chemical Structure
PARP7/HDACs-IN-1
- CAS No.: 3030144-11-4
- Formula:C29H33F3N8O6
- Molecular Weight:646.62
InChIKey: BIFMDHUVYGGFCU-GHOSXJJBSA-N
SMILES: O=C1NN=CC(N[C@H](COCCC(N2CCN(CC2)C3=NC=C(C=N3)OCC4=CC=C(C=C4)/C=C/C(NO)=O)=O)C)=C1C(F)(F)F
Biological Activity: PARP7/HDACs-IN-1 (compound 9l) is a dual-target inhibitor targeting PARP7/HDAC with anti-tumor activity. PARP7/HDACs-IN-1 inhibits different subtypes of PARPs and HDACs with IC50s of 83.3 nM (PARP1), 3.1 nM (PARP7), 35 nM (HDAC1), 30.3 nM (HDAC2), 35.4 nM (HDAC3), and 6.4 nM respectively. (HDAC6)[1]. br/[1].
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PARP7/HDACs-IN-1 | PARP7/HDACs-IN-1 (compound 9l) is a dual-target inhibitor targeting PARP7/HDAC with anti-tumor activity. PARP7/HDACs-IN-1 inhibits different subtypes of PARPs and HDACs with IC50s of 83.3 nM (PARP1), 3.1 nM (PARP7), 35 nM (HDAC1), 30.3 nM (HDAC2), 35.4 nM (HDAC3), and 6.4 nM respectively. (HDAC6). br/. | |||||||||||||||||||||
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References
Keywords
