1. PROTAC
    Epigenetics
    Cell Cycle/DNA Damage
  2. PROTAC
    PARP
  3. PROTAC PARP1 degrader

PROTAC PARP1 degrader 

Cat. No.: HY-114324
Handling Instructions

PROTAC PARP1 degrader is a PARP1 degrader based on the PROTAC technology. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

For research use only. We do not sell to patients.

PROTAC PARP1 degrader Chemical Structure

PROTAC PARP1 degrader Chemical Structure

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Description

PROTAC PARP1 degrader is a PARP1 degrader based on the PROTAC technology. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

IC50 & Target[1]

PARP1

 

MDM2

 

Molecular Weight

1145.09

Formula

C₅₈H₆₃Cl₂N₁₁O₁₀

SMILES

O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[[email protected]](C3=CC=C(Cl)C=C3)[[email protected]@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN6N=NC(C7=CC=C(N8N=C(C(C(N)=O)=CC=C9)C9=C8)C=C7)=C6)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PROTAC PARP1 degrader
Cat. No.:
HY-114324
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